Muscarinic receptor activation increases hERG channel expression through phosphorylation of ubiquitin ligase Nedd4-2

T Wang, A Hogan-Cann, Y Kang, Z Cui, J Guo… - Molecular …, 2014 - ASPET
The human ether-à-go-go–related gene (hERG) encodes the pore-forming subunit of the
rapidly activating delayed rectifier potassium channel, which is important for cardiac …

[HTML][HTML] Proteolytic cleavage in the S1–S2 linker of the Kv1. 5 channel does not affect channel function

A Hogan-Cann, W Li, J Guo, T Yang, S Zhang - Biochimica et Biophysica …, 2016 - Elsevier
Kv1.5 channels mediate the ultra-rapidly activating delayed rectifier potassium current (I Kur
), which is important for atrial repolarization. It has been shown that cell-surface Kv1.5 …

Proteolytic Cleavage of the Kv1. 5 Channel in the S1-S2 Linker Does Not Affect Channel Function

A Hogan-Cann - 2015 - library-archives.canada.ca
Atrial fibrillation (AF), the most prevalent human cardiac arrhythmia, is characterized by
rapid and disorderly electrical activity in the atria of the heart. Kv1. 5 channel mediated ultra-…

Proteolytic Digestion Reveals Novel Insights into the Kv1. 5 Structure‐Function Relationship

A HoganCann, S Zhang - The FASEB Journal, 2015 - Wiley Online Library
Atrial fibrillation (AF) is the most common form of cardiac arrhythmia. Kv1.5 channel mediated
ultra‐rapidly activating delayed rectifier potassium current (I Kur ) is important for atrial …

Unique Sensitivity to Extracellular Proteases and Peptide Protection of the HERG Potassium Channel

S Zhang, J Guo, S Lamothe, A HoganCann… - The FASEB …, 2015 - Wiley Online Library
The human ether‐a‐go‐go–related gene (hERG) encodes the pore‐forming subunit of the
rapidly activating delayed rectifier potassium channel (I Kr ), which is important for cardiac …

Endothelial NMDA receptors mediate activity-dependent brain hemodynamic responses in mice

AD Hogan-Cann, P Lu… - Proceedings of the …, 2019 - National Acad Sciences
Dynamic coupling of blood supply with energy demand is a natural brain property that
requires signaling between synapses and endothelial cells. Our previous work showed that …

Canadian Consortium on Neurodegeneration in Aging (CCNA) Partners Forum and Science Days 2022: Abstracts from the Poster Sessions, October 11–14, 2022

…, A Astell, D Guimarães, A Hogan-Cann… - Canadian Geriatrics …, 2023 - europepmc.org
Study Objectives To characterize the impact of CPAP use on cognition in a clinical cohort
with obstructive sleep apnea (OSA) and cognitive impairment due to neurodegenerative or …

[PDF][PDF] Susceptibility of the hERG Potassium Channel to Proteases and its Clinical Implications

S Lamothe - 2018 - qspace.library.queensu.ca
Cardiovascular diseases are the leading cause of death worldwide. Cardiac ischemia
accounts for approximately 50% of all cardiovascular-related deaths. Cardiac ischemia is …

Deletion of Grin1 in mouse megakaryocytes reveals NMDA receptor role in platelet function and proplatelet formation

JI Hearn, TN Green, CL Hisey, M Bender… - Blood, The Journal …, 2022 - ashpublications.org
The process of proplatelet formation (PPF) requires coordinated interaction between
megakaryocytes (MKs) and the extracellular matrix (ECM), followed by a dynamic reorganization of …

Nonionotropic action of endothelial NMDA receptors on blood–brain barrier permeability via Rho/ROCK-mediated phosphorylation of myosin

A Mehra, S Guérit, R Macrez, F Gosselet… - Journal of …, 2020 - Soc Neuroscience
Increase in blood–brain barrier (BBB) permeability is a crucial step in neuroinflammatory
processes. We previously showed that N Methyl D Aspartate Receptor (NMDARs), expressed …