Muscarinic receptor activation increases hERG channel expression through phosphorylation of ubiquitin ligase Nedd4-2
T Wang, A Hogan-Cann, Y Kang, Z Cui, J Guo… - Molecular …, 2014 - ASPET
The human ether-à-go-go–related gene (hERG) encodes the pore-forming subunit of the
rapidly activating delayed rectifier potassium channel, which is important for cardiac …
rapidly activating delayed rectifier potassium channel, which is important for cardiac …
[HTML][HTML] Proteolytic cleavage in the S1–S2 linker of the Kv1. 5 channel does not affect channel function
A Hogan-Cann, W Li, J Guo, T Yang, S Zhang - Biochimica et Biophysica …, 2016 - Elsevier
Kv1.5 channels mediate the ultra-rapidly activating delayed rectifier potassium current (I Kur
), which is important for atrial repolarization. It has been shown that cell-surface Kv1.5 …
), which is important for atrial repolarization. It has been shown that cell-surface Kv1.5 …
Proteolytic Cleavage of the Kv1. 5 Channel in the S1-S2 Linker Does Not Affect Channel Function
A Hogan-Cann - 2015 - library-archives.canada.ca
Atrial fibrillation (AF), the most prevalent human cardiac arrhythmia, is characterized by
rapid and disorderly electrical activity in the atria of the heart. Kv1. 5 channel mediated ultra-…
rapid and disorderly electrical activity in the atria of the heart. Kv1. 5 channel mediated ultra-…
Proteolytic Digestion Reveals Novel Insights into the Kv1. 5 Structure‐Function Relationship
A Hogan‐Cann, S Zhang - The FASEB Journal, 2015 - Wiley Online Library
Atrial fibrillation (AF) is the most common form of cardiac arrhythmia. Kv1.5 channel mediated
ultra‐rapidly activating delayed rectifier potassium current (I Kur ) is important for atrial …
ultra‐rapidly activating delayed rectifier potassium current (I Kur ) is important for atrial …
Unique Sensitivity to Extracellular Proteases and Peptide Protection of the HERG Potassium Channel
S Zhang, J Guo, S Lamothe, A Hogan‐Cann… - The FASEB …, 2015 - Wiley Online Library
The human ether‐a‐go‐go–related gene (hERG) encodes the pore‐forming subunit of the
rapidly activating delayed rectifier potassium channel (I Kr ), which is important for cardiac …
rapidly activating delayed rectifier potassium channel (I Kr ), which is important for cardiac …
Endothelial NMDA receptors mediate activity-dependent brain hemodynamic responses in mice
AD Hogan-Cann, P Lu… - Proceedings of the …, 2019 - National Acad Sciences
Dynamic coupling of blood supply with energy demand is a natural brain property that
requires signaling between synapses and endothelial cells. Our previous work showed that …
requires signaling between synapses and endothelial cells. Our previous work showed that …
Canadian Consortium on Neurodegeneration in Aging (CCNA) Partners Forum and Science Days 2022: Abstracts from the Poster Sessions, October 11–14, 2022
…, A Astell, D Guimarães, A Hogan-Cann… - Canadian Geriatrics …, 2023 - europepmc.org
Study Objectives To characterize the impact of CPAP use on cognition in a clinical cohort
with obstructive sleep apnea (OSA) and cognitive impairment due to neurodegenerative or …
with obstructive sleep apnea (OSA) and cognitive impairment due to neurodegenerative or …
[PDF][PDF] Susceptibility of the hERG Potassium Channel to Proteases and its Clinical Implications
S Lamothe - 2018 - qspace.library.queensu.ca
Cardiovascular diseases are the leading cause of death worldwide. Cardiac ischemia
accounts for approximately 50% of all cardiovascular-related deaths. Cardiac ischemia is …
accounts for approximately 50% of all cardiovascular-related deaths. Cardiac ischemia is …
Deletion of Grin1 in mouse megakaryocytes reveals NMDA receptor role in platelet function and proplatelet formation
The process of proplatelet formation (PPF) requires coordinated interaction between
megakaryocytes (MKs) and the extracellular matrix (ECM), followed by a dynamic reorganization of …
megakaryocytes (MKs) and the extracellular matrix (ECM), followed by a dynamic reorganization of …
Nonionotropic action of endothelial NMDA receptors on blood–brain barrier permeability via Rho/ROCK-mediated phosphorylation of myosin
A Mehra, S Guérit, R Macrez, F Gosselet… - Journal of …, 2020 - Soc Neuroscience
Increase in blood–brain barrier (BBB) permeability is a crucial step in neuroinflammatory
processes. We previously showed that N Methyl D Aspartate Receptor (NMDARs), expressed …
processes. We previously showed that N Methyl D Aspartate Receptor (NMDARs), expressed …