Discovery of novel targets of quinoline drugs in the human purine binding proteome
…, R Ray, K Hardeman, AM Coley, M Foley… - Molecular …, 2002 - ASPET
The quinolines have been used in the treatment of malaria, arthritis, and lupus for many
years, yet the precise mechanism of their action remains unclear. In this study, we used a …
years, yet the precise mechanism of their action remains unclear. In this study, we used a …
Selection and affinity maturation of IgNAR variable domains targeting Plasmodium falciparum AMA1
…, L Doughty, M Hattarki, AM Coley… - PROTEINS …, 2004 - Wiley Online Library
The new antigen receptor (IgNAR) is an antibody unique to sharks and consists of a
disulphide‐bonded dimer of two protein chains, each containing a single variable and five constant …
disulphide‐bonded dimer of two protein chains, each containing a single variable and five constant …
[HTML][HTML] Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody
AM Coley, A Gupta, VJ Murphy, T Bai, H Kim… - PLoS …, 2007 - journals.plos.org
Identifying functionally critical regions of the malaria antigen AMA1 (apical membrane antigen
1) is necessary to understand the significance of the polymorphisms within this antigen for …
1) is necessary to understand the significance of the polymorphisms within this antigen for …
[PDF][PDF] Structure of an IgNAR-AMA1 complex: targeting a conserved hydrophobic cleft broadens malarial strain recognition
KA Henderson, VA Streltsov, AM Coley, O Dolezal… - Structure, 2007 - cell.com
Apical membrane antigen 1 (AMA1) is essential for invasion of erythrocytes and hepatocytes
by Plasmodium parasites and is a leading malarial vaccine candidate. Although …
by Plasmodium parasites and is a leading malarial vaccine candidate. Although …
Binding Hot Spot for Invasion Inhibitory Molecules on Plasmodium falciparum Apical Membrane Antigen 1
KS Harris, JL Casey, AM Coley… - Infection and …, 2005 - Am Soc Microbiol
Apical membrane antigen 1 (AMA1) is expressed in schizont-stage malaria parasites and
sporozoites and is thought to be involved in the invasion of host red blood cells. AMA1 is an …
sporozoites and is thought to be involved in the invasion of host red blood cells. AMA1 is an …
Rapid and precise epitope mapping of monoclonal antibodies against Plasmodium falciparum AMA1 by combined phage display of fragments and random peptides
AM Coley, NV Campanale, JL Casey… - Protein …, 2001 - academic.oup.com
We describe an approach for the rapid mapping of epitopes within a malaria antigen using a
combination of phage display techniques. Phage display of antigen fragments identifies the …
combination of phage display techniques. Phage display of antigen fragments identifies the …
Green fluorescent antibodies: novel in vitro tools
We produced a fluorescent antibody as a single recombinant protein in Escherichia coli by
fusing a red-shifted mutant of green fluorescent protein (EGFP) to a single-chain antibody …
fusing a red-shifted mutant of green fluorescent protein (EGFP) to a single-chain antibody …
Structure of domain III of the blood-stage malaria vaccine candidate, Plasmodium falciparum apical membrane antigen 1 (AMA1)
Apical membrane antigen 1 of the malarial parasite Plasmodium falciparum (Pf AMA1) is a
merozoite antigen that is considered a strong candidate for inclusion in a malaria vaccine. …
merozoite antigen that is considered a strong candidate for inclusion in a malaria vaccine. …
[HTML][HTML] Rapid optimization of a peptide inhibitor of malaria parasite invasion by comprehensive N-methyl scanning
KS Harris, JL Casey, AM Coley, JA Karas… - Journal of Biological …, 2009 - ASBMB
Apical membrane antigen 1 (AMA1) of the malaria parasite Plasmodium falciparum has been
implicated in the invasion of host erythrocytes and is an important vaccine candidate. We …
implicated in the invasion of host erythrocytes and is an important vaccine candidate. We …
[HTML][HTML] Phage-displayed peptides bind to the malarial protein apical membrane antigen-1 and inhibit the merozoite invasion of host erythrocytes
F Li, A Dluzewski, AM Coley, A Thomas, L Tilley… - Journal of Biological …, 2002 - ASBMB
Apical membrane antigen-1 (AMA1) is a transmembrane protein present on the surface of
merozoites that is thought to be involved in the process of parasite invasion of host …
merozoites that is thought to be involved in the process of parasite invasion of host …