Structural basis of ligand binding modes at the neuropeptide YY1 receptor

Z Yang, S Han, M Keller, A Kaiser, BJ Bender, M Bosse… - Nature, 2018 - nature.com
Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and
have important roles in food intake, anxiety and cancer biology 1 , 2 . The NPY–Y receptor …

[HTML][HTML] Structural basis for ligand recognition of the neuropeptide YY2 receptor

T Tang, C Hartig, Q Chen, W Zhao, A Kaiser… - Nature …, 2021 - nature.com
The human neuropeptide Y (NPY) Y 2 receptor (Y 2 R) plays essential roles in food intake,
bone formation and mood regulation, and has been considered an important drug target for …

[HTML][HTML] Capturing peptide–GPCR interactions and their dynamics

A Kaiser, I Coin - Molecules, 2020 - mdpi.com
Many biological functions of peptides are mediated through G protein-coupled receptors (GPCRs).
Upon ligand binding, GPCRs undergo conformational changes that facilitate the …

[HTML][HTML] Pharmacological and functional similarities of the human neuropeptide Y system in C. elegans challenges phylogenetic views on the FLP/NPR system

MM Gershkovich, VE Groß, A Kaiser… - Cell Communication and …, 2019 - Springer
Background The neuropeptide Y system affects various processes, among others food intake,
and is frequently discussed in the context of targeting obesity. Studies in model organisms …

Unwinding of the C‐Terminal Residues of Neuropeptide Y is critical for Y2 Receptor Binding and Activation

A Kaiser, P Müller, T Zellmann… - Angewandte Chemie …, 2015 - Wiley Online Library
Despite recent breakthroughs in the structural characterization of G‐protein‐coupled receptors
(GPCRs), there is only sparse data on how GPCRs recognize larger peptide ligands. …

[HTML][HTML] Expression, functional characterization, and solid-state NMR investigation of the G protein-coupled GHS receptor in bilayer membranes

S Schrottke, A Kaiser, G Vortmeier, S Els-Heindl… - Scientific Reports, 2017 - nature.com
The expression, functional reconstitution and first NMR characterization of the human
growth hormone secretagogue (GHS) receptor reconstituted into either DMPC or POPC …

[PDF][PDF] Structural model of ghrelin bound to its G protein-coupled receptor

BJ Bender, G Vortmeier, S Ernicke, M Bosse, A Kaiser… - Structure, 2019 - cell.com
The peptide ghrelin targets the growth hormone secretagogue receptor 1a (GHSR) to signal
changes in cell metabolism and is a sought-after therapeutic target, although no structure is …

The conformational equilibrium of the neuropeptide Y2 receptor in bilayer membranes

…, J Becker‐Baldus, F Bernhard, A Kaiser… - Angewandte Chemie …, 2020 - Wiley Online Library
Dynamic structural transitions within the seven‐transmembrane bundle represent the mechanism
by which G‐protein‐coupled receptors convert an extracellular chemical signal into an …

Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors

…, M Keller, J Kofoed, S Reedtz-Runge, A Kaiser… - Science …, 2022 - science.org
In response to three highly conserved neuropeptides, neuropeptide Y (NPY), peptide YY, and
pancreatic polypeptide (PP), four G protein–coupled receptors mediate multiple essential …

Different mode of arrestin-3 binding at the human Y1 and Y2 receptor

L Wanka, S Babilon, A Kaiser, K Mörl… - Cellular signalling, 2018 - Elsevier
GPCR internalization, which is induced by arrestin recruitment, is an important mechanism
for the regulation of signaling and receptor quantity at the cell surface. In this study, …