User profiles for Anjan Debnath
 | Anjan DebnathFlorida International University Verified email at fiu.edu Cited by 210 |
A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target
A Debnath, D Parsonage, RM Andrade, C He… - Nature medicine, 2012 - nature.com
Entamoeba histolytica, a protozoan intestinal parasite, is the causative agent of human
amebiasis. Amebiasis is the fourth leading cause of death and the third leading cause of …
amebiasis. Amebiasis is the fourth leading cause of death and the third leading cause of …
[HTML][HTML] Cysteine proteases in protozoan parasites
JL Siqueira-Neto, A Debnath, LI McCall… - PLoS neglected …, 2018 - journals.plos.org
Cysteine proteases (CPs) play key roles in the pathogenesis of protozoan parasites, including
cell/tissue penetration, hydrolysis of host or parasite proteins, autophagy, and evasion or …
cell/tissue penetration, hydrolysis of host or parasite proteins, autophagy, and evasion or …
A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lamblia
…, D Leitsch, J Santini, A Debnath… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Giardiasis is one of the most common causes of diarrheal disease worldwide. Treatment is
primarily with 5-nitro antimicrobials, particularly metronidazole. Resistance to metronidazole …
primarily with 5-nitro antimicrobials, particularly metronidazole. Resistance to metronidazole …
Effect of the herbicides oxadiazon and oxyfluorfen on phosphates solubilizing microorganisms and their persistence in rice fields
AC Das, A Debnath, D Mukherjee - Chemosphere, 2003 - Elsevier
A field experiment has been conducted with two herbicides viz. oxadiazon [5-terbutyl-3-(2,4-dichloro-5-isopropoxyphenyl)-1,3,4-oxadiazol-2-one]
and oxyfluorfen [2-chloro-1-(3-ethoxy-4…
and oxyfluorfen [2-chloro-1-(3-ethoxy-4…
[HTML][HTML] Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis
…, C Marcellino, JH McKerrow, A Debnath… - PLoS neglected …, 2015 - journals.plos.org
Two major human diseases caused by filariid nematodes are onchocerciasis, or river
blindness, and lymphatic filariasis, which can lead to elephantiasis. The drugs ivermectin, …
blindness, and lymphatic filariasis, which can lead to elephantiasis. The drugs ivermectin, …
Effect of systemic herbicides on N2-fixing and phosphate solubilizing microorganisms in relation to availability of nitrogen and phosphorus in paddy soils of West …
AC Das, A Debnath - Chemosphere, 2006 - Elsevier
A field experiment has been conducted with four systemic herbicides viz., butachlor [N-(butoxymethyl)-2-chloro-2′,6′-diethyl-acetanilide],
fluchloralin [N-(2-chloroethyl)-(2,6-dinitro-N-…
fluchloralin [N-(2-chloroethyl)-(2,6-dinitro-N-…
X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action
D Parsonage, F Sheng, K Hirata, A Debnath… - Journal of structural …, 2016 - Elsevier
The anti-arthritic gold-containing drug Auranofin is lethal to the protozoan intestinal parasite
Entamoeba histolytica, the causative agent of human amebiasis, in both culture and animal …
Entamoeba histolytica, the causative agent of human amebiasis, in both culture and animal …
Corifungin, a new drug lead against Naegleria, identified from a high-throughput screen
A Debnath, JB Tunac, S Galindo-Gómez… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Primary amebic meningoencephalitis (PAM) is a rapidly fatal infection caused by the free-living
ameba Naegleria fowleri . The drug of choice in treating PAM is the antifungal antibiotic …
ameba Naegleria fowleri . The drug of choice in treating PAM is the antifungal antibiotic …
Naegleria fowleri after 50 years: is it a neglected pathogen?
…, D Coronado-Velázquez, A Debnath… - Journal of medical …, 2016 - microbiologyresearch.org
It has been 50 years since the first case of primary amoebic meningoencephalitis (PAM), an
acute and rapidly fatal disease of the central nervous system (CNS), was reported in …
acute and rapidly fatal disease of the central nervous system (CNS), was reported in …
Reprofiled drug targets ancient protozoans: drug discovery for parasitic diarrheal diseases
A Debnath, M Ndao, SL Reed - Gut microbes, 2013 - Taylor & Francis
Recently, we developed a novel automated, high throughput screening (HTS) methodology
for the anaerobic intestinal parasite Entamoeba histolytica. We validated this HTS platform …
for the anaerobic intestinal parasite Entamoeba histolytica. We validated this HTS platform …