Cannabidiol: State of the art and new challenges for therapeutic applications

S Pisanti, AM Malfitano, E Ciaglia, A Lamberti… - Pharmacology & …, 2017 - Elsevier
Over the past years, several lines of evidence support a therapeutic potential of Cannabis
derivatives and in particular phytocannabinoids. Δ 9 -THC and cannabidiol (CBD) are the most …

Pharmacological actions of statins: a critical appraisal in the management of cancer

P Gazzerro, MC Proto, G Gangemi, AM Malfitano… - Pharmacological …, 2012 - ASPET
Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently, a …

Anandamide inhibits adhesion and migration of breast cancer cells

…, C Laezza, AM Malfitano, A Santoro, M Vitale… - Experimental cell …, 2006 - Elsevier
The endocannabinoid system regulates cell proliferation in human breast cancer cells. We
reasoned that stimulation of cannabinoid CB 1 receptors could induce a non-invasive …

[HTML][HTML] Tumor-associated macrophage status in cancer treatment

AM Malfitano, S Pisanti, F Napolitano, S Di Somma… - Cancers, 2020 - mdpi.com
Tumor-associated macrophages (TAMs) represent the most abundant innate immune cells
in tumors. TAMs, exhibiting anti-inflammatory phenotype, are key players in cancer …

What we know and do not know about the cannabinoid receptor 2 (CB2)

AM Malfitano, S Basu, K Maresz, M Bifulco… - Seminars in …, 2014 - Elsevier
It has been well appreciated that the endocannabinoid system can regulate immune
responses via the cannabinoid receptor 2 (CB2), which is primarily expressed by cells of the …

The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits human breast cancer cell proliferation through a lipid raft-mediated mechanism

…, P Gazzerro, AM Malfitano, C Laezza, M Bifulco - Molecular …, 2006 - ASPET
The endocannabinoid system has been shown to modulate key cell-signaling pathways
involved in cancer cell growth. In this study, we show that cannabinoid receptor type 1 (CB1) …

Update on the endocannabinoid system as an anticancer target

AM Malfitano, E Ciaglia, G Gangemi… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: Recent studies have shown that the endocannabinoid system (ECS) could offer
an attractive antitumor target. Numerous findings suggest the involvement of this system (…

Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents

S Pisanti, AM Malfitano, C Grimaldi, A Santoro… - Best Practice & …, 2009 - Elsevier
Cannabinoids (the active components of Cannabis sativa) and their derivatives have
received renewed interest in recent years due to their diverse pharmacological activities. In …

[HTML][HTML] Anandamide inhibits the Wnt/β-catenin signalling pathway in human breast cancer MDA MB 231 cells

…, A D'Alessandro, S Paladino, AM Malfitano… - European Journal of …, 2012 - Elsevier
We previously showed that methyl-F-anandamide, a stable analogue of the anandamide,
inhibited the growth and the progression of cultured human breast cancer cells. As …

Statins in neurological disorders: an overview and update

AM Malfitano, G Marasco, MC Proto, C Laezza… - Pharmacological …, 2014 - Elsevier
Statins have, at present, the potential to provide a new therapeutic target for various
neurological diseases. It is well established that statins reduce cholesterol levels and prevent …