The multikinase inhibitor sorafenib is currently the treatment of reference for advanced
hepatocellular carcinoma (HCC). In our report, we examined the cytotoxic effects of sorafenib on …

The pathogenic bacterium Helicobacter pylori produces the cytotoxin VacA, which is
implicated in the genesis of gastric epithelial lesions. By transfect ing HEp‐2 cells with DNAs …

Talin is a structural component of focal adhesion sites and is thought to be engaged in
multiple protein interactions at the cytoplasmic face of cell/matrix contacts. Talin is a major link …

Sorafenib is the treatment of reference for advanced hepatocellular carcinoma (HCC), the
most frequent form of primary liver tumour. The loss of function of the retinoblastoma (Rb) …

Alpha-foetoprotein (AFP), one of the first protein tumour markers discovered, is widely used
today in clinical practice. Its application for the screening and diagnosis of hepatocellular …

Sorafenib is currently the medical treatment of reference for hepatocellular carcinoma (HCC),
but it is not known whether sorafenib is equally active in all HCC. Here, our aim was to …

Human tumors often trigger a hypercoagulable state that promotes hemostatic complications,
including venous thromboembolism. The recent application of systems biology to the study …

Background Sorafenib, a kinase inhibitor active against various solid tumours, induces oxidative
stress and ferroptosis, a new form of oxidative necrosis, in some cancer cells. Clinically-…

Helicobacter pylori vacuolating toxin (VacA) causes vacuolation in a variety of cultured cell
lines, sensitivity to VacA differing greatly, however, among the different cell types. We found …

Objective Solid tumors often establish a procoagulable state that can lead to venous
thromboembolism (VTE). Although some of the key genes involved in this process are known, no …