User profiles for Audrey Ferrand
Audrey FerrandTeam Leader INSERM, Institut de Recherche en Santé Digestive Verified email at inserm.fr Cited by 1650 |
Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib
R Mulloy, A Ferrand, Y Kim, R Sordella, DW Bell… - Cancer research, 2007 - AACR
Somatic mutations within the epidermal growth factor receptor (EGFR) kinase domain are
detected in 10% to 30% of human non–small cell lung cancers and are correlated with striking …
detected in 10% to 30% of human non–small cell lung cancers and are correlated with striking …
[HTML][HTML] Characterization of human colon organoids from inflammatory bowel disease patients
…, S Chabot, P Lluel, S Allart, A Ferrand… - Frontiers in cell and …, 2020 - frontiersin.org
Inflammatory Bowel Diseases (IBD) are chronic inflammatory disorders, where epithelial
defects drive, at least in part, some of the pathology. We reconstituted human intestinal …
defects drive, at least in part, some of the pathology. We reconstituted human intestinal …
Gastrin and cancer: a review
In 1905, a Cambridge physiologist, John Sydney Edkins, initially identified a hormone
responsible of gastric acid secretion, which he called gastric secretin, or gastrin. While gastrin's …
responsible of gastric acid secretion, which he called gastric secretin, or gastrin. While gastrin's …
Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway
Phosphatidylinositol 3‐kinase (PI3K) regulates many cellular functions including growth and
survival, and its excessive activation is a hallmark of cancer. Somatostatin, acting through …
survival, and its excessive activation is a hallmark of cancer. Somatostatin, acting through …
Critical role of Src and SHP-2 in sst2 somatostatin receptor-mediated activation of SHP-1 and inhibition of cell proliferation
The G protein-coupled sst2 somatostatin receptor acts as a negative cell growth regulator.
Sst2 transmits antimitogenic signaling by recruiting and activating the tyrosine phosphatase …
Sst2 transmits antimitogenic signaling by recruiting and activating the tyrosine phosphatase …
[HTML][HTML] Latest advances in targeting the tumor microenvironment for tumor suppression
The tumor bulk is composed of a highly heterogeneous population of cancer cells, as well
as a large variety of resident and infiltrating host cells, extracellular matrix proteins, and …
as a large variety of resident and infiltrating host cells, extracellular matrix proteins, and …
[HTML][HTML] A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models
A Ferrand, A Kowalski-Chauvel, C Bertrand… - Journal of Biological …, 2005 - ASBMB
To date very few G protein-coupled receptors (GPCRs) have been shown to be connected
to the Janus kinase (JAK)/STAT pathway. Thus our understanding of the mechanisms …
to the Janus kinase (JAK)/STAT pathway. Thus our understanding of the mechanisms …
[HTML][HTML] Protease-activated receptors in the intestine: focus on inflammation and cancer
Protease-activated receptors (PARs) belong to the G protein-coupled receptor (GPCR) family.
Compared to other GPCRs, the specificity of the four PARs is the lack of physiologically …
Compared to other GPCRs, the specificity of the four PARs is the lack of physiologically …
[HTML][HTML] NOD2 expression in intestinal epithelial cells protects toward the development of inflammation and associated carcinogenesis
Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition
receptor that senses bacterial peptidoglycan-conserved motifs in cytosol and stimulates host …
receptor that senses bacterial peptidoglycan-conserved motifs in cytosol and stimulates host …
[HTML][HTML] Extracellular matrix mechanical properties and regulation of the intestinal stem cells: when mechanics control fate
…, D Hamel, J Foncy, L Malaquin, A Ferrand - Cells, 2020 - mdpi.com
Intestinal stem cells (ISC) are crucial players in colon epithelium physiology. The accurate
control of their auto-renewal, proliferation and differentiation capacities provides a constant …
control of their auto-renewal, proliferation and differentiation capacities provides a constant …