User profiles for Audrey Ferrand

Audrey Ferrand

Team Leader INSERM, Institut de Recherche en Santé Digestive
Verified email at inserm.fr
Cited by 1650

Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib

R Mulloy, A Ferrand, Y Kim, R Sordella, DW Bell… - Cancer research, 2007 - AACR
Somatic mutations within the epidermal growth factor receptor (EGFR) kinase domain are
detected in 10% to 30% of human non–small cell lung cancers and are correlated with striking …

[HTML][HTML] Characterization of human colon organoids from inflammatory bowel disease patients

…, S Chabot, P Lluel, S Allart, A Ferrand… - Frontiers in cell and …, 2020 - frontiersin.org
Inflammatory Bowel Diseases (IBD) are chronic inflammatory disorders, where epithelial
defects drive, at least in part, some of the pathology. We reconstituted human intestinal …

Gastrin and cancer: a review

A Ferrand, TC Wang - Cancer letters, 2006 - Elsevier
In 1905, a Cambridge physiologist, John Sydney Edkins, initially identified a hormone
responsible of gastric acid secretion, which he called gastric secretin, or gastrin. While gastrin's …

Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway

…, E Archer‐Lahlou, F Lopez, M Fanjul, A Ferrand… - The EMBO …, 2006 - embopress.org
Phosphatidylinositol 3‐kinase (PI3K) regulates many cellular functions including growth and
survival, and its excessive activation is a hallmark of cancer. Somatostatin, acting through …

Critical role of Src and SHP-2 in sst2 somatostatin receptor-mediated activation of SHP-1 and inhibition of cell proliferation

G Ferjoux, F Lopez, JP Esteve, A Ferrand… - Molecular biology of …, 2003 - Am Soc Cell Biol
The G protein-coupled sst2 somatostatin receptor acts as a negative cell growth regulator.
Sst2 transmits antimitogenic signaling by recruiting and activating the tyrosine phosphatase …

[HTML][HTML] Latest advances in targeting the tumor microenvironment for tumor suppression

…, JJ Fournié, B Couderc, C Bousquet, A Ferrand… - International journal of …, 2019 - mdpi.com
The tumor bulk is composed of a highly heterogeneous population of cancer cells, as well
as a large variety of resident and infiltrating host cells, extracellular matrix proteins, and …

[HTML][HTML] A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models

A Ferrand, A Kowalski-Chauvel, C Bertrand… - Journal of Biological …, 2005 - ASBMB
To date very few G protein-coupled receptors (GPCRs) have been shown to be connected
to the Janus kinase (JAK)/STAT pathway. Thus our understanding of the mechanisms …

[HTML][HTML] Protease-activated receptors in the intestine: focus on inflammation and cancer

…, N Sola-Tapias, E Mas, F Barreau, A Ferrand - Frontiers in …, 2019 - frontiersin.org
Protease-activated receptors (PARs) belong to the G protein-coupled receptor (GPCR) family.
Compared to other GPCRs, the specificity of the four PARs is the lack of physiologically …

[HTML][HTML] NOD2 expression in intestinal epithelial cells protects toward the development of inflammation and associated carcinogenesis

A Ferrand, Z Al Nabhani, NS Tapias, E Mas… - Cellular and molecular …, 2019 - Elsevier
Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition
receptor that senses bacterial peptidoglycan-conserved motifs in cytosol and stimulates host …

[HTML][HTML] Extracellular matrix mechanical properties and regulation of the intestinal stem cells: when mechanics control fate

…, D Hamel, J Foncy, L Malaquin, A Ferrand - Cells, 2020 - mdpi.com
Intestinal stem cells (ISC) are crucial players in colon epithelium physiology. The accurate
control of their auto-renewal, proliferation and differentiation capacities provides a constant …