Pulmonary defense against environmental injury depends on airway mucus, which traps
inhaled toxins that are then cleared from the lungs by ciliary beating and cough. This review …

Mucus hypersecretion is a phenotype associated with multiple obstructive lung diseases.
However, in spite of its nefarious reputation under pathologic conditions, there are significant …

Markedly upregulated production of MUC5AC together with stimulated secretion leads to
airflow obstruction in asthma. As MUC5B appears to mediate homeostatic functions, it may be …

Background The mutations that have been implicated in pulmonary fibrosis account for only
a small proportion of the population risk. Methods Using a genomewide linkage scan, we …

Respiratory surfaces are exposed to billions of particulates and pathogens daily. A protective
mucus barrier traps and eliminates them through mucociliary clearance (MCC) 1 , 2 . …

Airway mucus hypersecretion is a prominent feature of many obstructive lung diseases. We
thus determined the ontogeny and exocytic phenotype of mouse airway mucous cells. In …

De novo expression of Muc5ac, a mucin not normally expressed in the intestinal tract, is
induced in the cecum of mice resistant to Trichuris muris infection. In this study, we investigated …

… A conditional mutant mouse has been generated, although its phenotype in the airway
has not yet been described (BF Dickey, unpublished observations). In hematopoietic cells, …

In asthma, airflow obstruction is thought to result primarily from inflammation-triggered
airway smooth muscle (ASM) contraction. However, anti-inflammatory and smooth muscle-…

Biochemical and genetic data suggest that synaptotagmin-2 functions as a Ca 2+ sensor for
fast neurotransmitter release in caudal brain regions, but animals and/or synapses lacking …