Potassium channels are tetrameric membrane proteins that selectively conduct K+ across
cellular membranes. With 78 family members, K+ channels make up about half of the …

… (B) Sodium channel mutations that have not been examined functionally in oocytes. Solid
circles denote those detected in more than one species and down triangles for those from a …

… Zhorov. We thank past and current lab members for their significant contributions to our …
Dong, K.; Du, Y.; Rinkevich, F.; Nomura, Y.; Xu, P.; Wang, L.; Silver, K.; Zhorov, BS Molecular …

… 1B). Within a few milliseconds after sodium channel opening, … 1B) and plays an important
role in the termination of an action … 1B), which allows the cell membrane to regain its resting …

… (B and C) Percentage of channel modification by deltamethrin of rNa v 1.2 (B) and rNa v 1.4
(C) and mutant channels. The number of oocytes for each mutant channel was >5. Error bars …

1,4-Dihydropyridines were introduced in the last century for the treatment of coronary
diseases. Then medicinal chemists decorated the 1,4-DHP nucleus, the most studied scaffold …

… Denis B. Tikhonov, Boris S. Zhorov; Mechanism of sodium channel block by local anesthetics,
antiarrhythmics, and anticonvulsants. J Gen Physiol 3 April 2017; 149 (4): 465–481. doi: …

In the last decade, the idea of common organization of certain ion channel families exhibiting
diverse physiological and pharmacological properties has received strong experimental …

A large body of experimental data on Na + channels is available, but the interpretation of these
data in structural terms is difficult in the absence of a high-resolution structure. Essentially …

1,4-Dihydropyridines (DHPs) constitute a major class of ligands for L-type Ca 2+ channels (LTCC).
The DHPs have a boat-like, six-membered ring with an NH group at the stern, an …