Although much attention has been paid to the removal of hormones from sera and to the
development of serum-free media for studies on hormone-responsive cells in culture, little …

Estrogens are known to regulate the proliferation of breast cancer cells and to alter their
cytoarchitectural and phenotypic properties, but the gene networks and pathways by which …

We have found that certain tetrasubstituted pyrazoles are high-affinity ligands for the
estrogen receptor (ER) (Fink et al. Chem. Biol. 1999, 6, 205−219) and that one pyrazole is …

Estrogenic hormones, believed to exert most of their effects via the direct interaction of their
receptors with chromatin, are found to increase cAMP in target breast cancer and uterine …

Through an effort to develop novel ligands that have subtype selectivity for the estrogen
receptors alpha (ERα) and beta (ERβ), we have found that 2,3-bis(4-hydroxyphenyl)propionitrile …

The selective action that steroid hormones and the hormones for the other nuclear receptors
have in different tissues and on different responses is well known. In fact, this recognized …

We have used a transient transfection system with a cytomegalovirus-based vector expressing
high levels of biologically active human estrogen receptor (ER) in COS-1 cells to study …

Previous studies from this laboratory have shown that the heavy metal cadmium (Cd) mimics
the effects of estradiol in estrogen-responsive breast cancer cell lines. To understand the …

Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy,
we mapped estrogen receptor α (ERα) binding sites in MCF-7 breast cancer cells. We …

Estrogens regulate the growth, differentiation, and functioning of diverse target tissues, both
within and outside of the reproductive system. Most of the actions of estrogens appear to be …