Cloning and functional expression of the human histamine H3 receptor

TW Lovenberg, BL Roland, SJ Wilson, X Jiang… - Molecular …, 1999 - ASPET
Histamine regulates neurotransmitter release in the central and peripheral nervous systems
through H 3 presynaptic receptors. The existence of the histamine H 3 receptor was …

Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies

JD Roth, BL Roland, RL Cole… - Proceedings of the …, 2008 - National Acad Sciences
Body weight is regulated by complex neurohormonal interactions between endocrine signals
of long-term adiposity (eg, leptin, a hypothalamic signal) and short-term satiety (eg, amylin, …

Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein …

…, JR Voland, Y Wu, K Ngo, BL Roland… - The American journal of …, 2000 - Elsevier
Tangier disease (TD) and familial HDL deficiency (FHA) have recently been linked to
mutations in the human ATP-binding cassette transporter 1 (hABCA1), a member of the ABC …

Anatomical distribution of prolactin-releasing peptide and its receptor suggests additional functions in the central nervous system and periphery

BL Roland, SW Sutton, SJ Wilson, L Luo, J Pyati… - …, 1999 - academic.oup.com
A recently identified neuropeptide with PRL-releasing capabilities binds to and activates a
previously known orphan G protein-coupled receptor, GPR10. We initiated a study to define …

Glucocorticoid receptor, mineralocorticoid receptors, 11β-hydroxysteroid dehydrogenase-1 and-2 expression in rat brain and kidney: in situ studies

BL Roland, ZS Krozowski, JW Funder - Molecular and cellular …, 1995 - Elsevier
In mammals, 11β-hydroxysteroid dehydrogenase (11-HSD) activity allows aldosterone
occupancy of mineralocorticoid receptors (MR) by inactivating endogenous glucocorticoids. The …

Noradrenergic neurons of the area postrema mediate amylin's hypophagic action

…, VF Turek, RL Cole, C Vu, BL Roland… - American Journal …, 2010 - journals.physiology.org
Circulating amylin inhibits food intake via activation of the area postrema (AP). The aim of
this study was to identify the neurochemical phenotype of the neurons mediating amylin's …

Localization of 11beta-hydroxysteroid dehydrogenase type 2 in rat tissues: in situ studies

BL Roland, JW Funder - Endocrinology, 1996 - academic.oup.com
In the rat, the enzyme 11beta-hydroxysteroid dehydrogenase 2 (11betaHSD2) converts the
glucocorticoid corticosterone into receptor-inactive 11-dehydrocorticosterone, thereby …

Hybridization histochemical localization of 11 beta-hydroxysteroid dehydrogenase type 2 in rat brain

BL Roland, KX Li, JW Funder - Endocrinology, 1995 - academic.oup.com
11 beta-hydroxysteroid dehydrogenase (11-HSD) activity allows aldosterone occupancy of
mineralocorticoid receptors by inactivating endogenous glucocorticoids. The expression of …

Implications of amylin receptor agonism: integrated neurohormonal mechanisms and therapeutic applications

JD Roth, H Maier, S Chen, BL Roland - Archives of neurology, 2009 - jamanetwork.com
States as an antihyperglycemic agent in patients with type 1 or type 2 DM treated with mealtime
insulin. 1 Further clinical testing of pramlintide in subjects with obesity demonstrated that …

Brain dopamine D2 receptor mRNA levels are elevated in young spontaneously hypertensive rats

CE Vaughan, M van den Buuse, BL Roland - Neuroscience research, 1999 - Elsevier
Levels of brain dopamine D 2 receptor expression were compared between spontaneously
hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) controls by quantitative in …