Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene
…, P Dollé, E Tzavara, J Hanoune, BP Roques… - Nature, 1996 - nature.com
DESPITE tremendous efforts in the search for safe, efficacious and non-addictive opioids for
pain treatment, morphine remains the most valuable painkiller in contemporary medicine. …
pain treatment, morphine remains the most valuable painkiller in contemporary medicine. …
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB1 Receptor Knockout Mice
…, GA Bohme, A Imperato, T Pedrazzini, BP Roques… - Science, 1999 - science.org
The function of the central cannabinoid receptor (CB 1 ) was investigated by invalidating its
gene. Mutant mice did not respond to cannabinoid drugs, demonstrating the exclusive role of …
gene. Mutant mice did not respond to cannabinoid drugs, demonstrating the exclusive role of …
The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore
…, D Cointe, ZH Xie, JC Reed, BP Roques… - The Journal of …, 2000 - rupress.org
Viral protein R (Vpr) encoded by HIV-1 is a facultative inducer of apoptosis. When added to
intact cells or purified mitochondria, micromolar and submicromolar doses of synthetic Vpr …
intact cells or purified mitochondria, micromolar and submicromolar doses of synthetic Vpr …
[HTML][HTML] Absence of opiate rewarding effects in mice lacking dopamine D2 receptors
…, A Saiardi, O Valverde, TA Samad, BP Roques… - Nature, 1997 - nature.com
Dopamine receptors have been implicated in the behavioural response to drugs of abuse.
These responses are mediated particularly by the mesolimbic dopaminergic pathway arising …
These responses are mediated particularly by the mesolimbic dopaminergic pathway arising …
International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors
…, J Bradwejn, KB Seroogy, M Hamon, BP Roques - Pharmacological …, 1999 - ASPET
The peptide cholecystokinin (CCK) 2 was originally discovered in the gastrointestinal tract (Ivy
and Oldberg, 1928) and has been shown to mediate pancreatic secretion and contraction …
and Oldberg, 1928) and has been shown to mediate pancreatic secretion and contraction …
[HTML][HTML] Disruption of the κ-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ-agonist U …
…, I Kitchen, A Dierich, M Le Meur, BP Roques… - The EMBO …, 1998 - embopress.org
… Although habituation to the number of squares crossed was stronger in the group of mutant
mice (P <0.05 on the third day) than in the wild-type group (ns on the third day), there were no …
mice (P <0.05 on the third day) than in the wild-type group (ns on the third day), there were no …
First glimpses at structure-function relationships of the nucleocapsid protein of retroviruses
…, H de Rocquigny, BP Roques - Journal of molecular …, 1995 - Elsevier
Retroviruses are a family of widespread small animal viruses about 110 nm in diameter,
composed of an inner core surrounded by an outer envelope formed of a lipid bilayer of cellular …
composed of an inner core surrounded by an outer envelope formed of a lipid bilayer of cellular …
Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding
KS Gajiwala, H Chen, F Cornille, BP Roques, W Reith… - Nature, 2000 - nature.com
Regulatory factor X (RFX) proteins are transcriptional activators that recognize X-boxes (DNA
of the sequence 5′-GTNRCC(0–3N)RGYAAC-3′, where N is any nucleotide, R is a …
of the sequence 5′-GTNRCC(0–3N)RGYAAC-3′, where N is any nucleotide, R is a …
Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of …
…, E Chauvel, BP Roques, P Corvol… - Proceedings of the …, 1996 - National Acad Sciences
Angiotensin (Ang) II and Ang III are two peptide effectors of the brain renin-angiotensin
system that participate in the control of blood pressure and increase water consumption and …
system that participate in the control of blood pressure and increase water consumption and …
Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein R and Bcl-2
…, L Edelman, ZH Xie, JC Reed, BP Roques… - The Journal of …, 2001 - rupress.org
Viral protein R (Vpr), an apoptogenic accessory protein encoded by HIV-1, induces
mitochondrial membrane permeabilization (MMP) via a specific interaction with the permeability …
mitochondrial membrane permeabilization (MMP) via a specific interaction with the permeability …