Alzheimer's disease constitutes a rising threat to public health. Despite extensive research
in cellular and animal models, identifying the pathogenic agent present in the human brain …

… We thank members of the Sabatini and Selkoe laboratories for helpful discussions and critical
… Selkoe at the above address, dselkoe{at}rics.bwh.harvard.edu; or Bernardo L. Sabatini at …

▪ Abstract Spines are neuronal protrusions, each of which receives input typically from one
excitatory synapse. They contain neurotransmitter receptors, organelles, and signaling …

Background Laser scanning microscopy is a powerful tool for analyzing the structure and
function of biological specimens. Although numerous commercial laser scanning microscopes …

… We thank all members of the Sabatini Lab for helpful insights, E. Spooner for the mass …
We thank all members of the Sabatini Lab for helpful insights, E. Spooner for the mass …

All-optical electrophysiology—spatially resolved simultaneous optical perturbation and
measurement of membrane voltage—would open new vistas in neuroscience research. We …

Spine Ca 2+ is critical for the induction of synaptic plasticity, but the factors that control Ca 2+
handling in dendritic spines under physiological conditions are largely unknown. We …

Among the many neuromodulators used by the mammalian brain to regulate circuit function
and plasticity, dopamine (DA) stands out as one of the most behaviorally powerful. …

In excitatory neurons, most glutamatergic synapses are made on the heads of dendritic
spines, each of which houses the postsynaptic terminal of a single glutamatergic synapse. We …

The substantia nigra pars compacta and ventral tegmental area contain the two largest
populations of dopamine-releasing neurons in the mammalian brain. These neurons extend …