Niemann–Pick C1-like protein (NPC1L1) mediates the absorption of dietary cholesterol in
the proximal region of the intestine, a process that is blocked by cholesterol absorption …

35 S-labeled derivatives of the insecticides nodulisporic acid and ivermectin were synthesized
and demonstrated to bind with high affinity to a population of receptors in Drosophila …

A series of benzodiazepines and benzazepinones were synthesized and evaluated as
potential sodium channel blockers in a functional, membrane potential-based assay. One …

Voltage-gated calcium channel (Ca v )2.2 (N-type calcium channels) are key components in
nociceptive transmission pathways. Ziconotide, a state-independent peptide inhibitor of Ca …

The discovery of novel therapeutic agents that act on voltage-gated sodium channels requires
the establishment of high-capacity screening assays that can reliably measure the activity …

Voltage-gated sodium channels (Nav1) transmit pain signals from peripheral nociceptive
neurons, and blockers of these channels have been shown to ameliorate a number of pain …

… Williams, DP McHale, JN Wood, FM Gribble, CG Woods … Ritter, MM Smith, VA Warren,
BS Williams, GJ Kaczorowski, WH Parsons … JP Felix, BS Williams, BT Priest, RM Brochu …

Voltage-gated sodium channels are known to be expressed in neurons and other excitable
cells. Recently, voltage-gated sodium channels have been found to be expressed in human …

A series of imidazopyridines were evaluated as potential sodium channel blockers for the
treatment of neuropathic pain. Several members were identified with good hNa v 1.7 potency …

Sodium channel blockers are used clinically to treat a number of neuropathic pain conditions,
but more potent and selective agents should improve on the therapeutic index of currently …