In the brain and heart, rapidly inactivating (A-type) voltage-gated potassium (Kv) currents
operate at subthreshold membrane potentials to control the excitability of neurons and cardiac …

Endocannabinoids (eCBs) function as retrograde signaling molecules at synapses throughout
the brain, regulate axonal growth and guidance during development, and drive adult …

The differential expression and association of cytoplasmic β-subunits with pore-forming α-subunits
may contribute significantly to the complexity and heterogeneity of voltage-gated K + …

Voltage-gated potassium (Kv) channels from the Kv4, or Shal-related, gene family underlie
a major component of the A-type potassium current in mammalian central neurons. We …

Endocannabinoids are lipid molecules that serve as natural ligands for the cannabinoid
receptors CB1 and CB2. They modulate a diverse set of physiological processes such as pain, …

Neuropathic pain resulting from nerve lesions or dysfunction represents one of the most
challenging neurological diseases to treat. A better understanding of the molecular mechanisms …

Validation of gait analysis has the potential to bridge the gap between data from animal pain
models and clinical observations. The goal of these studies was to compare alterations in …

Potassium channels are key determinants of neuronal excitability. We recently identified
KChIPs as a family of calcium binding proteins that coassociate and colocalize with Kv4 family …

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are responsible for the
functional hyperpolarization-activated current (I h ) in dorsal root ganglion (DRG) neurons, …

Here, we have investigated the in vitro pharmacology of a muscarinic agonist, (3R,4R)-3-(3-hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane
(WAY-132983), and we …