Substituted 4-acylpyrazoles and 4-acylpyrazolones: synthesis and multidrug resistance-modulating activity

…, G Bechmann, K Lorenz, B Plagens… - Journal of medicinal …, 1998 - ACS Publications
A series of 4-acyl-3-pyrazolone derivatives with a 3-substituted 2-hydroxy-3-aminopropyl
chain attached to pyrazole N-1 (7−20) as well as isomeric 4-acyl-5-(3-substituted 3-amino-2-…

Identification of Ligand-Binding Regions of P-Glycoprotein by Activated-Pharmacophore Photoaffinity Labeling and Matrix-Assisted Laser Desorption/Ionization–Time …

GF Ecker, E Csaszar, S Kopp, B Plagens, W Holzer… - Molecular …, 2002 - ASPET
Energy dependent efflux pumps confer resistance to anticancer, antimicrobial, and
antiparasitic drugs. P-glycoprotein (Pgp, ABCB1) mediates resistance to a broad spectrum of …

4-Acyl-5-methyl-2-phenylpyrazolones: NMR and X-ray structure investigations

W Holzer, K Mereiter, B Plagens - Heterocycles, 1999 - infona.pl
1H- and 1 3 C-NMR investigations with 4-acyl-5-methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-ones
(1-6) are presented, indicating these compounds to exist predominantely as …

Alkylation of pyrazolones via the Mitsunobu reaction

W Holzer, B Plagens, K Lorenz - Heterocycles, 1997 - infona.pl
The reaction of 3-methyl-1-phenyl-2-pyrazolin-5-one and 4-acyl derivatives thereof (R 4=
COPh, 2-thienoyl, COCH 2 CH 2 Ph, COCH= CHPh) with various alcohols under Mitsunobu …

[PDF][PDF] Division Differentiation and Carcinogenesis (B0600)

…, A Wollschläger, M Kegel, B Nagel-Plagens - researchgate.net
In vitro and in vivo studies of this group as well as others have clearly documented the
essential role of epithelialmesenchymal interactions for keratinocyte growth and tissue …

Tumorigenic conversion of immortal human keratinocytes through stromal cell activation

M Skobe, NE Fusenig - Proceedings of the National …, 1998 - National Acad Sciences
… We gratefully acknowledge the expert secretarial assistance of Martina Kegel and stylistic
improvements by Brigitte Nagel-Plagens. These studies were in part supported by the …

Tumorigenic conversion of immortal human skin keratinocytes (HaCaT) by elevated temperature

P Boukamp, S Popp, K Bleuel, E Tomakidi, A Bürkle… - Oncogene, 1999 - nature.com
… , Dirk Breitkreutz for critical discussions, and Brigitte Plagens for stylistic improvements. We
also wish to extend our thanks to Brigitte Engelhardt and coworkers for their excellent photo …

Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes.

C Härle-Bachor, P Boukamp - Proceedings of the national …, 1996 - National Acad Sciences
… Jackie Bickenbach and Brigitte Plagens for critically reading this manuscript. This work
was supported by Deutsche Forschungsgemeinschaft Grant Bo-2-1 (to PB) and a short-term …

Localization of prostaglandin H synthase isoenzymes in murine epidermal tumors: Suppression of skin tumor promotion by inhibition of prostaglandin H synthase‐2

K Müller‐Decker, A Kopp‐Schneider… - … in cooperation with …, 1998 - Wiley Online Library
… We would like to thank Dagmar Kucher, Brigitte Steinbauer, Iris Moll, and Ina Schuster for
their technical assistance. The editorial assistance of Brigitte Plagens is gratefully …

Constitutive expression of 8‐lipoxygenase in papillomas and clastogenic effects of lipoxygenase‐derived arachidonic acid metabolites in keratinocytes

F Bürger, P Krieg, A Kinzig, B Schurich… - … in cooperation with …, 1999 - Wiley Online Library
… We would like to thank Ina Kutschera and Brigitte Steinbauer for excellent technical assistance.
The editorial assistance of Brigitte Plagens is gratefully acknowledged. This project was …