Protection of the Cyp1a2 (−/−) null mouse against uroporphyria and hepatic injury following exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin

AG Smith, B Clothier, P Carthew, NL Childs… - Toxicology and applied …, 2001 - Elsevier
The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the liver of C57BL/6J mice is a
model for clinical sporadic porphyria cutanea tarda (PCT). There is massive uroporphyria, …

Rapid aging of neurotoxic esterase after inhibition by di-isopropyl phosphorofluoridate

B Clothier, MK Johnson - Biochemical Journal, 1979 - portlandpress.com
1. It was proposed [Johnson (1974) J. Neurochem.23, 785–789] that an essential step in the
genesis of delayed neuropathy caused by some organophosphorus esters was aging of …

Interaction between iron metabolism and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism

AG Smith, B Clothier, S Robinson, MJ Scullion… - Molecular …, 1998 - ASPET
The binding of 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) with the aryl hydrocarbon (AH)
receptor and subsequent changes in gene expression have been studied intensively, but the …

Genetic variation of basal iron status, ferritin and iron regulatory protein in mice: potential for modulation of oxidative stress

B Clothier, S Robinson, RA Akhtar, JE Francis… - Biochemical …, 2000 - Elsevier
Toxic and carcinogenic free radical processes induced by drugs and other chemicals are
probably modulated by the participation of available iron. To see whether endogenous iron …

Hepatic gene expression in protoporphyic Fech mice is associated with cholestatic injury but not a marked depletion of the heme regulatory pool

R Davies, A Schuurman, CR Barker, B Clothier… - The American journal of …, 2005 - Elsevier
BALB/c Fech m1Pas mice have a mutated ferrochelatase gene resulting in protoporphyria
that models the hepatic injury occurring sporadically in human erythropoietic protoporphyria. …

Essential Role of the AH Receptor in the Dysfunction of Heme Metabolism Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

R Davies, B Clothier, SW Robinson… - Chemical research in …, 2008 - ACS Publications
The dysfunction of hepatic heme synthesis by 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) in
mice, enhanced by iron, leads to accumulation of uroporphyrins I and III (uroporphyria) and …

Protoporphyria induced by the orally active iron chelator 1, 2-diethyl-3-hydroxypyridin-4-one in C57BL/10ScSn mice

AG Smith, B Clothier, JE Francis… - Blood, The Journal …, 1997 - ashpublications.org
Administration in the drinking water of the orally-active iron chelator 1,2-diethyl-3-hydroxypyridin-4-one
(CP94) to C57BL/10ScSn mice caused the development of hepatic …

Non-ahr gene susceptibility loci for porphyria and liver injury induced by the interaction of 'dioxin'with iron overload in mice

SW Robinson, B Clothier, RA Akhtar, AL Yang… - Molecular …, 2002 - ASPET
Among the actions of 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) in mice is the induction of
hepatic porphyria. This is similar to the most common disease of this type in humans, …

Uroporphyria induced by 5-aminolaevulinic acid alone in Ahrd SWR mice

D Constantin, JE Francis, RA Akhtar, B Clothier… - Biochemical …, 1996 - Elsevier
In mice, depression of hepatic uroporphyrinogen decarboxylase (UROD) leading to porphyrin
accumulation (uroporphyria) occurs with chlorinated ligands of the aryl hydrocarbon (AH) …

[PDF][PDF] Multiple polymorphic loci determine basal hepatic and splenic iron status in mice

GR Grant, SW Robinson, RE Edwards, B Clothier… - …, 2006 - Wiley Online Library
Polymorphisms of genes linked to iron metabolism may account for individual variability in
hemochromatosis and iron status connected with liver and cardiovascular diseases, cancers, …