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Activated microglia contribute to the maintenance of chronic pain after spinal cord injury

BC Hains, SG Waxman - Journal of Neuroscience, 2006 - Soc Neuroscience
Traumatic spinal cord injury (SCI) results not only in motor impairment but also in chronic
central pain, which can be refractory to conventional treatment approaches. It has been shown …

Upregulation of sodium channel Nav1. 3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury

BC Hains, JP Klein, CY Saab, MJ Craner… - Journal of …, 2003 - Soc Neuroscience
Spinal cord injury (SCI) can result in hyperexcitability of dorsal horn neurons and central
neuropathic pain. We hypothesized that these phenomena are consequences, in part, of …

Mechanisms of chronic central neuropathic pain after spinal cord injury

CE Hulsebosch, BC Hains, ED Crown, SM Carlton - Brain research reviews, 2009 - Elsevier
Not all spinal contusions result in mechanical allodynia, in which non-noxious stimuli
become noxious. The studies presented use the NYU impactor at 12.5 mm drop or the Infinite …

Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury

BC Hains, CY Saab, JP Klein, MJ Craner… - Journal of …, 2004 - Soc Neuroscience
Peripheral nerve injury is known to upregulate the rapidly repriming Na v 1.3 sodium
channel within first-order spinal sensory neurons. In this study, we hypothesized that (1) after …

Sodium channels contribute to microglia/macrophage activation and function in EAE and MS

MJ Craner, TG Damarjian, S Liu, BC Hains, AC Lo… - Glia, 2005 - Wiley Online Library
Loss of axons is a major contributor to nonremitting deficits in the inflammatory demyelinating
disease multiple sclerosis (MS). Based on biophysical studies showing that activity of …

Co‐localization of sodium channel Nav1.6 and the sodium–calcium exchanger at sites of axonal injury in the spinal cord in EAE

MJ Craner, BC Hains, AC Lo, JA Black, SG Waxman - Brain, 2004 - academic.oup.com
Axonal degeneration contributes to the development of non‐remitting neurological deficits
and disability in multiple sclerosis, but the molecular mechanisms that underlie axonal loss in …

Primary cortical motor neurons undergo apoptosis after axotomizing spinal cord injury

BC Hains, JA Black, SG Waxman - Journal of Comparative …, 2003 - Wiley Online Library
Spinal cord injury (SCI) results in loss of voluntary motor control followed by incomplete
recovery, which is partly mediated by the descending corticospinal tract (CST). This system is an …

Modulation of thalamic nociceptive processing after spinal cord injury through remote activation of thalamic microglia by cysteine–cysteine chemokine ligand 21

P Zhao, SG Waxman, BC Hains - Journal of Neuroscience, 2007 - Soc Neuroscience
Spinal cord injury (SCI) results in the generation and amplification of pain caused in part by
injury-induced changes in neuronal excitability at multiple levels along the sensory neuraxis. …

Extracellular signal-regulated kinase-regulated microglia–neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury

P Zhao, SG Waxman, BC Hains - Journal of Neuroscience, 2007 - Soc Neuroscience
Many patients with traumatic spinal cord injury (SCI) report pain that persists indefinitely and
is resistant to available therapeutic approaches. We recently showed that microglia become …

Changes in electrophysiological properties and sodium channel Nav1.3 expression in thalamic neurons after spinal cord injury

BC Hains, CY Saab, SG Waxman - Brain, 2005 - academic.oup.com
Spinal cord contusion injury (SCI) is known to induce pain-related behaviour, as well as
hyperresponsiveness in lumbar dorsal horn nociceptive neurons associated with the aberrant …
Did you mean to search for: Bryan CHains