PURPOSE: To determine the sensitivities of computed tomography (CT) and ultrasound (US)
for detection and characterization of surgically verified small renal lesions. MATERIALS …

Proteus syndrome is a sporadic disorder named for its highly variable manifestations. The
disease causes tissue overgrowth in a mosaic pattern and may affect tissues derived from any …

1. The main metabolites of rifampin and rifabutin in man are their respective 25 deacetylated
derivatives, but the enzyme(s) responsible for these biotransformations are not known. 2. In …

Taxol, a natural product initially isolated from the stem bark of the western yewTaxus brevifolia,
is undergoing phase II and III evaluation due to its reported activity against a variety of …

A series ofAdriamycin-resistant human breast MCF-7 and human colon DLD-1 cancer cell
lines were established by stepwise selection. The concentration of Adriamycin required to …

Human liver slices, human liver microsomes, and rat liver microsomes were used to investigate
the metabolism of 3 H-taxol. The effects of drugs frequently coadministered with taxol …

Suramin, a drug known to have antiparasitic effects, has been previously shown to have
adrenocorticolytic activity in primates. We now confirm preferential accumulation of this …

This study was performed to evaluate whether concomitant treatment with ketoconazole could
reduce the clearance of paclitaxel given to ovarian cancer patients. Paclitaxel, 175 mg/m 2…

Suramin, a polyanionic compound with known antiparasitic activity, has been shown to be
adrenocorticolytic in primates and to have clinical efficacy in the treatment of patients with …

Male Sprague-Dawley rats had their bile ducts cannulated and were dosed with [3H] taxol(2
mg/kg, 68-77 MCi/mg) as a continuous intravenous infusion for 6 hr so that the plasma …