This is a review of an approach to organizing data on chemical-chemical and chemical-biological
reactions in numerical mechanistic terms such that numerous comparisons can easily …

It has been nearly 40 years since the quantitative structure-activity relationship (QSAR)
paradigm first found its way into the practice of agrochemistry, pharmaceutical chemistry, …

This review sets out to survey the important contributions of physicochemical descriptors
that are utilized to characterize chemical reactivity as well as biological activity and to focus …

In this review, the evolution of QSAR is traced from the insightful observations of Crum-Brown
and Frazier to Hammett's critical equations and finally Hansch's seminal contributions on …

… The predicted log 1/C value from Table 3 is 5.62, while the experimental log 1/C value
recently measured by Selassie et al. (in press) is 3.86. While the mechanistic reason for this …

In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51
substituted phenols in a murine leukemia cell line (L1210), we determined the concentrations …

The multiple functions of the phenol moiety that are widely present in disparate sources such
as drugs, pesticides, teas, fuel additives and surfactants have not been clearly delineated. …

Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine and
thiopyrimidine drugs. If potent TPMT inhibitors were available, studies of the regulation and …

Ten esters each of caffeic acid and dihydrocaffeic acid have recently been synthesized.
Cytotoxicity evaluations of these esters versus L1210 leukemia and MCF-7 breast cancer cells in …

Despite the dramatic increase in speed of synthesis and biological evaluation of new chemical
entities, the number of compounds that survive the rigorous processes associated with …