Induction of drug-metabolizing enzymes by dioxin

JP Whitlock, CH Chichester, RM Bedgood… - Drug metabolism …, 1997 - Taylor & Francis
Several phase I and phase 11 drug-metabolizing enzymes have the interesting property of
being inducible; that is. following exposure of the cell to an inducing chemical, enzyme …

[HTML][HTML] Hypoxia-inducible mammalian gene expression analyzed in vivo at a TATA-driven promoter and at an initiator-driven promoter

ST Okino, CH Chichester, JP Whitlock - Journal of Biological Chemistry, 1998 - ASBMB
We have analyzed protein-DNA interactionsin vivo at transcriptional control elements for two
hypoxia-inducible genes in mouse hepatoma cells. The promoter for the phosphoglycerate …

Metabolism and cytotoxicity of naphthalene and its metabolites in isolated murine Clara cells.

CH Chichester, AR Buckpitt, A Chang… - Molecular pharmacology, 1994 - ASPET
Nonciliated bronchiolar epithelial (Clara) cells of mice are highly susceptible to toxicants that
undergo metabolic activation, presumably because this cell type expresses high levels of …

Characterization of the cytochrome P-450 monooxygenase system in nonciliated bronchiolar epithelial (Clara) cells isolated from mouse lung

CH Chichester, RM Philpot, AJ Weir… - American journal of …, 1991 - atsjournals.org
The nonciliated bronchiolar epithelial (Clara) cell of the mouse is highly susceptible to toxicants
that undergo metabolic activation, presumably because this cell type has high levels of …

Heterogeneity of Clara cell glutathione: a possible basis for differences in cellular responses to pulmonary cytotoxicants

JAA West, CH Chichester, AR Buckpitt… - American journal of …, 2000 - atsjournals.org
… Insertion of a 520-nm barrier filter removed all red emissions from the green channel (C)
and totally obscured the red channel (D). The confocal images from TMR chloride and BODIPY …

[BOOK][B] Cellular mechanisms of naphthalene cytotoxicity in isolated murine Clara cells

CH Chichester - 1993 - search.proquest.com
… system, the first chapter evaluates the direct relationship between … The second chapter
addresses the significance of covalent binding … The third chapter evaluates the importance of the …

Isolation of Nonciliated Bronchiolar

AM Malkinson, FB Miley, CH Chichester… - In Vitro Biological …, 2013 - books.google.com
Along with the liver and skin, the lung is one of the main organ systems exposed to environmental
toxins. A central role of Clara cells in determining the pulmonary response to these …

Synthesis of Centrally Labeled (15, 15')-β-Carotene

HH Inhoffen, U Schwieter, CO Chichester… - Journal of the …, 1955 - ACS Publications
Grignard acetylene is normally prepared with a large excess of the gas, reacting for a
considerable period. It is formed slowly, and the reaction is incomplete when the acetylene is …

[PDF][PDF] Space-the final chapter or why physical representations are not semantic intentions

A Dillon, J Richardson, C McKnight - 1993 - academia.edu
… In this chapter we will discuss navigation through hypertext in terms of its relevance as a
concept as much as its presence as an issue and try to draw lessons for design and research …

[CITATION][C] Field survey of Chichester Harbour 1982

C Cartwright - Sussex Archaeological Collections, 1984