… we predicted that this fragment represented the mouse analog of the C-terminal 17 kDa
human PS1 derivative. Curiously, when we compared the pattern of αPS1Loopimmunoreactive …

… in the presence of 20 μM I-labeled Aβ at 20C for 12 h in TBS, pH 7.4, supplemented with 1%
… , pH 7.4 (overnight at 20C), 6 M urea, pH 7.4 (3 h at 20C), 9 M urea, pH 11 (6 h at 20C). The …

… This preparation of oligomers was stable for at least 2 weeks if stored at 4 ◦ C (data not
shown). Afl fibrils were obtained from synthetic Afl40 peptides incubated at a concentration of 200 …

… ), and assuming that the hydrophobic C terminus of Aβ forms an intramolecular β-sheet,
we propose a model for Aβ-fibril formation (Fig. 8 D). The N terminus, considered not to be …

We have previously shown that short peptides incorporating the sequence KLVFF can bind
to the ∼40amino acid residue Alzheimer amyloid β-peptide (Aβ) and disrupt amyloid fibril …

The Alzheimer beta/A4 amyloid precursor protein (APP) can be proteolytically processed by
at least two separate pathways in PC12 cells: chloroquine-insensitive secretory cleavage …

… The multidomain protein has a C-terminal domain showing homology to blood coagulation
factors V and VIII. We found that the main constituent of aortic medial amyloid is a 50-aa-long …

… and then cleared by centrifugation (3O,OOOg, 4C for 60 min). The supernatant with the sol…
The plates were incubated at 4C for 150 min and the incubates were harvested by filtration …

… Moreover, the apoE part of the AB-apoE complexes appears to be composed of a C-terminal
fragment truncated at a site C-terminal to residue 158. This complexed apoE fragment is …

… Eventually, these networks either dissolve into monomers/dimers (Figure 2b.c) or
proceed into diffuse short fibrils (Figure 3b) and further into … was set to 254 nm and the c.alculations …