This review will concentrate on the clinical pharmacology, in particular pharmacodynamic
data, related to atypical antipsychotics, clozapine, risperidone, paliperidone, olanzapine, que¬ …

The behavioral effects of psychomotor stimulants such as amphetamine (AMPH) arise from
their ability to elicit increases in extracellular dopamine (DA). These AMPH-induced …

… After centrifugation at 1000g for 10 min at 4C, the pellet was discarded, and the supernatant
was centrifuged at 16,000g for 25 min at 4C. The resulting P2 pellet was placed on ice and …

… 62 ng/mL) and a lower than predicted degree of fluctuation between maximum plasma
concentration (C max ) and minimum plasma concentration (C min ) (53 vs. 145%) [68]. The …

… After 45 min at 37 C, the cells were then challenged with 10 μm DA or other agents in media
… ice-cold EBSS, and solubilized for 1 h at 4 C in 1 ml of solubilization buffer (50 mm HEPES, …

… 1C). With a similar approach we also observed the EC 50 value of dopamine to remain
constant with varying amounts of vector DNA used for transfection (Fig. 1D), indicating that spare …

We investigated the regulatory effects of GRK2 on D 2 dopamine receptor signaling and
found that this kinase inhibits both receptor expression and functional signaling in a …

… After centrifugation at 1000g for 10 min at 4C, the pellet was discarded, and the supernatant
was centrifuged at 16,000g for 25 min at 4C. The resulting P2 pellet was placed on ice and …

… -LR, and 1 μM aprotinin and leupeptin for 1 h at 4C. Cell lysates were recovered by
centrifugation at 20,000g for 30 min at 4C. Samples were then analyzed by SDS-PAGE (10% gel) …

Introduction: Paliperidone, the major active metabolite of risperidone, is a second-generation
antipsychotic that has been developed as an extended-release (ER) oral formulation and a …