User profiles for C. W. Lindsley
Craig LindsleyVanderbilt University Verified email at vanderbilt.edu Cited by 33440 |
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
…, A Christopoulos, CW Lindsley - Nature reviews Drug …, 2009 - nature.com
Despite G-protein-coupled receptors (GPCRs) being among the most fruitful targets for
marketed drugs, intense discovery efforts for several GPCR subtypes have failed to deliver …
marketed drugs, intense discovery efforts for several GPCR subtypes have failed to deliver …
The Akt/PKB pathway: molecular target for cancer drug discovery
JQ Cheng, CW Lindsley, GZ Cheng, H Yang… - Oncogene, 2005 - nature.com
The serine/threonine kinase Akt/PKB pathway presents an exciting new target for molecular
therapeutics, as it functions as a cardinal nodal point for transducing extracellular (growth …
therapeutics, as it functions as a cardinal nodal point for transducing extracellular (growth …
Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia
In recent years, the metabotropic glutamate (mGlu) receptors have emerged as potential
new drug targets for treatment of a range of CNS disorders. Some of the most compelling …
new drug targets for treatment of a range of CNS disorders. Some of the most compelling …
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors
CW Lindsley, Z Zhao, WH Leister, RG Robinson… - Bioorganic & medicinal …, 2005 - Elsevier
This letter describes the development of two series of potent and selective allosteric Akt
kinase inhibitors that display an unprecedented level of selectivity for either Akt1, Akt2 or both …
kinase inhibitors that display an unprecedented level of selectivity for either Akt1, Akt2 or both …
Efficient synthesis of imidazoles from aldehydes and 1, 2-diketones using microwave irradiation
…, WH Leister, Y Wang, Z Zhao, CW Lindsley - Organic …, 2004 - ACS Publications
A simple, high-yielding synthesis of 2,4,5-trisubstituted imidazoles from 1,2-diketones and
aldehydes in the presence of NH 4 OAc is described. Under microwave irradiation, alkyl-, aryl-…
aldehydes in the presence of NH 4 OAc is described. Under microwave irradiation, alkyl-, aryl-…
In Vivo Structure−Activity Relationship Study of Dorsomorphin Analogues Identifies Selective VEGF and BMP Inhibitors
The therapeutic potential of small molecule signaling inhibitors is often limited by off-target
effects. Recently, in a screen for compounds that perturb the zebrafish embryonic …
effects. Recently, in a screen for compounds that perturb the zebrafish embryonic …
Phospholipase D: enzymology, functionality, and chemical modulation
PE Selvy, RR Lavieri, CW Lindsley, HA Brown - Chemical reviews, 2011 - ACS Publications
Phosphatidic acid (PA) is a critical phospholipid constituent in eukaryotic cell membranes,
which accounts for 1Ą4% of the total lipid. 1 This lipophilic glycerophospholipid has a …
which accounts for 1Ą4% of the total lipid. 1 This lipophilic glycerophospholipid has a …
A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models
…, TB Chen, DD Wisnoski, CW Lindsley… - … of Pharmacology and …, 2005 - ASPET
We found that 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB) is a potent
and selective positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (…
and selective positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (…
Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders
Muscarinic acetylcholine receptors (mAChRs) have long been viewed as viable targets for
novel therapeutic agents for the treatment of Alzheimer's disease (AD) and other disorders …
novel therapeutic agents for the treatment of Alzheimer's disease (AD) and other disorders …
Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation
…, C Kreatsoulas, L Veng, CW Lindsley… - Proceedings of the …, 2009 - National Acad Sciences
The forebrain cholinergic system promotes higher brain function in part by signaling through
the M 1 muscarinic acetylcholine receptor (mAChR). During Alzheimer's disease (AD), …
the M 1 muscarinic acetylcholine receptor (mAChR). During Alzheimer's disease (AD), …