Cardiac K + channels are membrane-spanning proteins that allow the passive movement of
K + ions across the cell membrane along its electrochemical gradient. They regulate the …

Background Bupivacaine is a potent local anesthetic widely used for prolonged local and
regional anesthesia. However, accidental intravascular injection of bupivacaine can produce …

Dietary polyunsaturated fatty acids (PUFAs) have been reported to exhibit antiarrhythmic
properties, which have been attributed to their availability to modulate Na + , Ca 2+ , and …

Stereoselective drug-channel interactions may help to elucidate the molecular basis of
voltage-gated potassium channel block by local anesthetic drugs. We studied the effects of the …

Protein Kinase CK2 is a serine-threonine kinase frequently deregulated in many human
tumors. Here, we hypothesized that a peptide binder to the CK2 phosphoacceptor site could …

Diabetic foot ulcer is a principal diabetic complication. It has been shown that diabetic
patients have decreased growth factor concentrations in their tissues, particularly epidermal …

Voltage-dependent potassium (K v ) channels play a pivotal role in the modulation of
macrophage physiology. Macrophages are professional antigen-presenting cells and produce …

The mechanism of inhibition of Na + channels by lidocaine has been suggested to involve
low-affinity binding to rested states and high-affinity binding to the inactivated state of the …

Kv1.3 plays a crucial role in the activation and proliferation of T-lymphocytes and macrophages.
While Kv1.3 is responsible for the voltage-dependent potassium current in T-cells, in …

Background Cervical cancer is now considered the second leading cause of death among
women worldwide, and its incidence has reached alarming levels, especially in developing …