[HTML][HTML] Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging
C Simioni, G Zauli, AM Martelli, M Vitale, G Sacchetti… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Physical exercise is considered to be one of the beneficial factors of a proper lifestyle and is
nowadays seen as an indispensable element for good health, able to lower the risk of …
nowadays seen as an indispensable element for good health, able to lower the risk of …
[HTML][HTML] Adenosine receptors and cancer
Adenosine is a ubiquitous signaling molecule whose physiological functions are mediated
by its interaction with four G-protein-coupled receptor subtypes, termed A 1 , A 2A , A 2B and …
by its interaction with four G-protein-coupled receptor subtypes, termed A 1 , A 2A , A 2B and …
Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1α, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human …
Frequent coffee consumption has been associated with a reduced risk of colorectal cancer
in a number of case-control studies. Coffee is a leading source of methylxanthines, such as …
in a number of case-control studies. Coffee is a leading source of methylxanthines, such as …
Legislation to limit the environmental plastic and microplastic pollution and their influence on human exposure
I Conti, C Simioni, G Varano, C Brenna, E Costanzi… - Environmental …, 2021 - Elsevier
Plastic pollution is an emerging problem and is a consequence of the post-consumer plastic
waste accumulation in the environment coupled to mismanaged waste programmes. …
waste accumulation in the environment coupled to mismanaged waste programmes. …
[HTML][HTML] miR-199a-3p modulates MTOR and PAK4 pathways and inhibits tumor growth in a hepatocellular carcinoma transgenic mouse model
E Callegari, L D'Abundo, P Guerriero, C Simioni… - … Therapy-Nucleic Acids, 2018 - cell.com
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death
worldwide. Prognosis is poor, and therapeutic options are limited. MicroRNAs (miRNAs) have …
worldwide. Prognosis is poor, and therapeutic options are limited. MicroRNAs (miRNAs) have …
[HTML][HTML] miRNAs as influencers of cell–cell communication in tumor microenvironment
I Conti, G Varano, C Simioni, I Laface, D Milani… - Cells, 2020 - mdpi.com
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the
posttranscriptional level, inducing the degradation of the target mRNA or translational repression. …
posttranscriptional level, inducing the degradation of the target mRNA or translational repression. …
[HTML][HTML] Targeting mTOR in acute lymphoblastic leukemia
C Simioni, AM Martelli, G Zauli, E Melloni, LM Neri - Cells, 2019 - mdpi.com
Acute Lymphoblastic Leukemia (ALL) is an aggressive hematologic disorder and constitutes
approximately 25% of cancer diagnoses among children and teenagers. Pediatric patients …
approximately 25% of cancer diagnoses among children and teenagers. Pediatric patients …
[HTML][HTML] Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation
C Simioni, A Cani, AM Martelli, G Zauli, G Tabellini… - Oncotarget, 2014 - ncbi.nlm.nih.gov
… Neri LM, Cani A, Martelli AM, Simioni C, Junghanss C, Tabellini G, Ricci F, Tazzari PL,
Pagliaro P, McCubrey JA, Capitani S. Targeting the PI3K/Akt/mTOR signaling pathway in B-precursor …
Pagliaro P, McCubrey JA, Capitani S. Targeting the PI3K/Akt/mTOR signaling pathway in B-precursor …
A2B and A3 adenosine receptors modulate vascular endothelial growth factor and interleukin-8 expression in human melanoma cells treated with etoposide and …
Cancer patients undergoing treatment with systemic cancer chemotherapy drugs often have
abnormal growth factor and cytokine profiles. Thus, serum levels of interleukin-8 (IL-8) are …
abnormal growth factor and cytokine profiles. Thus, serum levels of interleukin-8 (IL-8) are …
[HTML][HTML] The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapy
C Simioni, AM Martelli, A Cani, R Cetin-Atalay… - Oncotarget, 2013 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most common potentially lethal human
malignancies worldwide. Advanced or recurrent HCC is frequently resistant to conventional …
malignancies worldwide. Advanced or recurrent HCC is frequently resistant to conventional …