Nuclear factor κB (NF-κB) is an inducible transcription factor that regulates genes important
in immunity and inflammation. The activity of NF-κB is highly regulated: transcriptionally …

Replication stress and DNA damage activate the ATR-Chk1 checkpoint signaling pathway
that licenses repair and cell survival processes. In this study, we examined the respective …

Mutations in the tumor suppressors BRCA1 and BRCA2, which encode proteins that are key
participants in homologous recombination (HR) repair, occur in ∼20% of high grade serous …

The Fanconi anemia (FA) network is important for the repair of interstrand DNA cross-links.
A key event in FA pathway activation is the monoubiquitylation of the FA complementation …

Resistance to platinum compounds is a major determinant of patient survival in high-grade
serous ovarian cancer (HGSOC). To understand mechanisms of platinum resistance and …

Signaling lymphocyte activation molecule (SLAM) family receptors are critically involved in
modulating innate and adaptive immune responses. Several SLAM family receptors have …

5-Fluorouracil (5-FU) and its metabolite 5-fluorodeoxyuridine (FdUrd, floxuridine) are
chemotherapy agents that are converted to 5-fluorodeoxyuridine monophosphate (FdUMP) and 5-…

Purpose Cytosine arabinoside (AraC) remains the backbone of most treatment regimens for
acute myeloid leukemia (AML). Incorporation of AraC into DNA activates checkpoint kinase …

… J Biol Chem … J Biol Chem … J Biol Chem …

Heat shock protein 90 (HSP90), which regulates the functions of multiple oncogenic signaling
pathways, has emerged as a novel anticancer therapeutic target, and multiple small-…