In cancer, the epithelial-to-mesenchymal transition (EMT) is associated with tumour stemness,
metastasis and resistance to therapy. It has recently been proposed that, rather than being …

Epithelial–mesenchymal transition (EMT) is a process in which epithelial cells acquire
mesenchymal features. In cancer, EMT is associated with tumor initiation, invasion, metastasis, …

FAT1, which encodes a protocadherin, is one of the most frequently mutated genes in human
cancers 1 , 2 , 3 , 4 – 5 . However, the role and the molecular mechanisms by which FAT1 …

The mammary epithelium is composed of several cell lineages including luminal, alveolar and
myoepithelial cells. Transplantation studies have suggested that the mammary epithelium …

Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization
from epithelial to mesenchymal phenotypes, which leads to functional changes in cell …

The maintenance and repair of many adult tissues are ensured by stem cells (SCs), which
reside at the top of the cellular hierarchy of these tissues. Functional assays, such as in vitro …

Recent studies using the isolation of a subpopulation of tumour cells followed by their
transplantation into immunodeficient mice provide evidence that certain tumours 1 , 2 , including …

Natural peptides displaying agonist activity on the orphan G protein-coupled receptor GPR54
were isolated from human placenta. These 54-, 14,- and 13-amino acid peptides, with a …

The skin epidermis and its array of appendages undergo ongoing renewal by a process
called homeostasis. Stem cells in the epidermis have a crucial role in maintaining tissue …

Dendritic cells (DCs) and macrophages are professional antigen-presenting cells (APCs)
that play key roles in both innate and adaptive immunity. ChemR23 is an orphan G protein–…