The visible spectrum of a ligand-bound cytochrome P450 is often used to determine the nature
of the interaction between the ligand and the P450. One particularly characteristic form of …

Sterol 14α-demethylases (CYP51) are the enzymes essential for sterol biosynthesis. They
serve as clinical targets for antifungal azoles and are considered as targets for treatment of …

CYP2C9 catalyzes the demethylation of the biphasic kinetics substrate (S)-naproxen, and
the CYP2C9*2 (R144C) and CYP2C9*3 (I359L) variants are associated with lower rates of (S)-…

Neurological side effects consistent with ivermectin toxicity have been observed in dogs
when high doses of the common heartworm prevention agent ivermectin are coadministered …

CYP2C9 metabolizes a wide range of drugs, many of which are negatively charged at
physiological pH. Therefore, it has been thought that complementarily charged amino acid(s) are …

Cytochrome P450 (P450) protein-protein interactions have been observed with various in
vitro systems. It is interesting to note that these interactions seem to be isoform-dependent, …

The hemoprotein cytochrome b 5 (cyt b5) has been demonstrated to affect the kinetics of
drug oxidation by the microsomal cytochromes P450 (P450s). However, the mechanisms …

Both orthosteric and allosteric antagonists of the group II metabotropic glutamate receptors (mGlus)
have been used to establish a link between mGlu 2/3 inhibition and a variety of CNS …

Noncovalent forces, other than hydrophobic interactions, are important determinants of
substrate bias exhibited by some cytochromes P450. The CYP2C9 pharmacophore is proposed …

Little information regarding the metabolic pathways of pharmaceutical agents administered
to dogs, or the inhibition of those metabolic pathways, is available. Without this information, it …