ROS are a risk factor of several cardiovascular disorders and interfere with NO/soluble guanylyl
cyclase/cyclic GMP (NO/sGC/cGMP) signaling through scavenging of NO and formation …

1 Chronic renal disease is associated with oxidative stress, reduced nitric oxide (NO)
availability and soluble guanylate cyclase (sGC) dysfunction. Recently, we discovered BAY 58‐…

Background Blinded independent central review (BICR) of radiographic images is frequently
conducted in oncology trials to address the potential bias of local evaluation (LE) of …

The ubiquitously expressed nitric oxide (NO) receptor soluble guanylate cyclase (sGC) plays
a key role in signal transduction. Binding of NO to the N-terminal prosthetic heme moiety of …

Soluble guanylate cyclase, a heterodimer consisting of an α- and a heme-containing β-subunit,
is the major receptor for the biological messenger nitric oxide (NO) and is involved in …

The ubiquitous heterodimeric nitric oxide (NO) receptor soluble guanylate cyclase (sGC)
plays a key role in various signal transduction pathways. Binding of NO takes place at the …

Oxidative stress, defined as an alteration in the balance between the production and removal
of reactive oxygen species (ROS), plays a central role in many cardiovascular diseases. …

The intracellular nitric oxide receptor, soluble guanylate cyclase (sGC), is an obligate
heterodimer of an α-and a smaller, heme-containing β-subunit. The prosthetic heme group is …

Soluble guanylate cyclase (sGC), the intracellular receptor for the ubiquitous biological
messenger NO, exists as heterodimer consisting of an α-and β-subunit. sGC contains a non-…

Background Multiple profilin isoforms exist in mammals; at least four are expressed in the
mammalian testis. The testis-specific isoforms profilin-3 (PFN3) and profilin-4 (PFN4) may have …