The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the …

…, Y Ge, K LaFiura, CL Haska, C Cherian… - Leukemia, 2009 - nature.com
We explored the impact of mutations in the NOTCH1, FBW7 and PTEN genes on prognosis
and downstream signaling in a well-defined cohort of 47 patients with pediatric T-cell acute …

Synthesis and Biological Activity of a Novel Series of 6-Substituted Thieno[2,3-d]pyrimidine Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate …

…, S Kugel Desmoulin, J Wu, C Cherian… - Journal of medicinal …, 2009 - ACS Publications
A series of seven 2-amino-4-oxo-6-substituted thieno[2,3-d]pyrimidines with bridge length
variations (from 2 to 8 carbon atoms) were synthesized as selective folate receptor (FR) α and …

Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity

Y Deng, Y Wang, C Cherian, Z Hou… - Journal of medicinal …, 2008 - ACS Publications
6-Substituted classical pyrrolo[2,3-d]pyrimidine antifolates with a three- to six-carbon bridge
between the heterocycle and the benzoyl-l-glutamate (compounds 2−5, respectively) were …

Synthesis and Antitumor Activity of a Novel Series of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitors of Purine Biosynthesis with Selectivity for …

L Wang, C Cherian, S Kugel Desmoulin… - Journal of medicinal …, 2010 - ACS Publications
2-Amino-4-oxo-6-substituted pyrrolo[2,3-d]pyrimidines with a thienoyl side chain and four to
six carbon bridge lengths (compounds 1−3) were synthesized as substrates for folate …

Synthesis, Biological, and Antitumor Activity of a Highly Potent 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitor with Proton-Coupled Folate …

L Wang, SK Desmoulin, C Cherian… - Journal of medicinal …, 2011 - ACS Publications
2-Amino-4-oxo-6-substituted pyrrolo[2,3-d]pyrimidine antifolates with a thienoyl side chain (compounds
1–3, respectively) were synthesized for comparison with compound 4, the …

Therapeutic targeting of a novel 6-substituted pyrrolo [2, 3-d] pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled …

…, K White, J Kushner, M Stout, Z Hou, C Cherian… - Molecular …, 2011 - ASPET
The proton-coupled folate transporter (PCFT) is a proton-folate symporter with an acidic pH
optimum. By real-time reverse transcription-polymerase chain reaction, PCFT was expressed …

Synthesis and Biological Activity of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Inhibitors of de Novo Purine Biosynthesis with Selectivity for …

L Wang, C Cherian, S Kugel Desmoulin… - Journal of medicinal …, 2012 - ACS Publications
We previously reported the selective transport of classical 2-amino-4-oxo-6-substituted
pyrrolo[2,3-d]pyrimidines with a thienoyl-for-benzoyl-substituted side chain and a three- (3a) and …

Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo [2, 3-d] pyrimidine antifolate inhibitors of de novo purine biosynthesis in …

…, A Fulterer, MH Chang, MF Romero, C Cherian… - Molecular …, 2010 - ASPET
The proton-coupled folate transporter (PCFT) is a folate-proton symporter with an acidic pH
optimum, approximating the microenvironments of solid tumors. We tested 6-substituted …

Discovery of 5-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4 …

…, MP Ravindra, E Hales, S Orr, C Cherian… - Journal of medicinal …, 2013 - ACS Publications
We synthesized 5-substituted pyrrolo[2,3-d]pyrimidine antifolates (compounds 5–10) with
one-to-six bridge carbons and a benozyl ring in the side chain as antitumor agents. Compound …

Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled …

C Cherian, S Kugel Desmoulin, L Wang, L Polin… - Cancer chemotherapy …, 2013 - Springer
Purpose We examined whether the novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl
antifolate, compound 2, might be an effective treatment for malignant pleural mesothelioma (…