The rich behavioral repertoire of animals is encoded in the CNS as a set of motorneuron
activation patterns, also called 'motor synergies'. However, the neurons that orchestrate these …

Dysfunction of microRNA (miRNA) metabolism is thought to underlie diseases affecting
motoneurons. One miRNA, miR-218, is abundantly and selectively expressed by developing and …

The spinal cord contains neural networks that enable regionally distinct motor outputs along
the body axis. Nevertheless, it remains unclear how segment-specific motor computations …

Electrophysiological and morphological properties of genetically identified spinal interneurons
were examined to elucidate their possible contribution to locomotor-like rhythmic activity …

Locomotor rhythm generation is a fundamental characteristic of neural networks in the spinal
cord. Identifying the synaptic interactions between neurons in the locomotor circuitry is key …

The coordination of multi-muscle movements originates in the circuitry that regulates the firing
patterns of spinal motorneurons. Sensory neurons rely on the musculotopic organization …

Identifying molecular mediators of neural circuit development and/or function that contribute
to circuit dysfunction when aberrantly reengaged in neurological disorders is of high …

10.7554/eLife.21540.001 Flexible neural networks, such as the interconnected spinal neurons
that control distinct motor actions, can switch their activity to produce different behaviors. …

Motor behaviors such as walking or withdrawing the limb from a painful stimulus rely upon
integrative multimodal sensory circuitry to generate appropriate muscle activation patterns. …

Voltage-gated sodium channels (Navs) are promising targets for analgesic and antiepileptic
therapies. Although specificity between Nav subtypes may be desirable to target specific …