The brain, appetite, and obesity
HR Berthoud, C Morrison - Annu. Rev. Psychol., 2008 - annualreviews.org
Food intake and energy expenditure are controlled by complex, redundant, and distributed
neural systems that reflect the fundamental biological importance of adequate nutrient supply …
neural systems that reflect the fundamental biological importance of adequate nutrient supply …
Cognitive impairment following high fat diet consumption is associated with brain inflammation
PJ Pistell, CD Morrison, S Gupta, AG Knight… - Journal of …, 2010 - Elsevier
C57Bl/6 mice were administered a high fat, Western diet (WD, 41% fat) or a very high fat
lard diet (HFL, 60% fat), and evaluated for cognitive ability using the Stone T-maze and for …
lard diet (HFL, 60% fat), and evaluated for cognitive ability using the Stone T-maze and for …
[HTML][HTML] FGF21 is an endocrine signal of protein restriction
…, TW Gettys, MW Schwartz, CD Morrison - The Journal of …, 2014 - Am Soc Clin Investig
Enhanced fibroblast growth factor 21 (FGF21) production and circulation has been linked to
the metabolic adaptation to starvation. Here, we demonstrated that hepatic FGF21 …
the metabolic adaptation to starvation. Here, we demonstrated that hepatic FGF21 …
Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia
KD Niswender, CD Morrison, DJ Clegg, R Olson… - Diabetes, 2003 - Am Diabetes Assoc
In peripheral tissues, insulin signaling involves activation of the insulin receptor substrate (IRS)-phosphatidylinositol
3-kinase (PI3K) enzyme system. In the hypothalamus, insulin …
3-kinase (PI3K) enzyme system. In the hypothalamus, insulin …
Structure, production and signaling of leptin
H Münzberg, CD Morrison - Metabolism, 2015 - Elsevier
The cloning of leptin in 1994 was an important milestone in obesity research. In those days
obesity was stigmatized as a condition caused by lack of character and self-control. …
obesity was stigmatized as a condition caused by lack of character and self-control. …
[HTML][HTML] Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons
GJ Morton, RW Gelling, KD Niswender, CD Morrison… - Cell metabolism, 2005 - cell.com
To investigate whether phosphatidylinositol-3 kinase (PI3K) signaling mediates the
metabolic effects of hypothalamic leptin action, adenoviral gene therapy was used to direct …
metabolic effects of hypothalamic leptin action, adenoviral gene therapy was used to direct …
[HTML][HTML] Blaming the brain for obesity: integration of hedonic and homeostatic mechanisms
HR Berthoud, H Münzberg, CD Morrison - Gastroenterology, 2017 - Elsevier
The brain plays a key role in the controls of energy intake and expenditure, and many genes
associated with obesity are expressed in the central nervous system. Technological and …
associated with obesity are expressed in the central nervous system. Technological and …
High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling
CD Morrison, PJ Pistell, DK Ingram… - Journal of …, 2010 - Wiley Online Library
… Recent work has implicated leptin in the regulation of cognitive function (Morrison 2009),
and circulating levels of leptin and brain leptin signaling are altered in settings of HFD …
and circulating levels of leptin and brain leptin signaling are altered in settings of HFD …
Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet
…, TL Hise, JN Keller, DK Ingram, CD Morrison… - Neurobiology of …, 2009 - Elsevier
This study was undertaken to investigate the effects of prenatal and postnatal exposure to
high fat diet on the brain. Female rats were divided into high fat diet (HFD) and control diet (CD…
high fat diet on the brain. Female rats were divided into high fat diet (HFD) and control diet (CD…
Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling
CD Morrison, GJ Morton… - American journal …, 2005 - journals.physiology.org
Phosphatidylinositol 3-OH-kinase (PI3K) and STAT3 are signal transduction molecules
activated by leptin in brain areas controlling food intake. To investigate their role in leptin-…
activated by leptin in brain areas controlling food intake. To investigate their role in leptin-…