Cannabinoid physiology and pharmacology: 30 years of progress

AC Howlett, CS Breivogel, SR Childers… - …, 2004 - Elsevier
Δ 9 -Tetrahydrocannabinol from Cannabis sativa is mimicked by cannabimimetic analogs
such as CP55940 and WIN55212-2, and antagonized by rimonabant and SR144528, through …

Evidence for a new G protein-coupled cannabinoid receptor in mouse brain

CS Breivogel, G Griffin, V Di Marzo, BR Martin - Molecular pharmacology, 2001 - ASPET
The purpose of these studies was to support the hypothesis that an undiscovered cannabinoid
receptor exists in brain. [ 35 S]GTPγS binding was stimulated by anandamide and …

Chronic ▵9‐Tetrahydrocannabinol Treatment Produces a Time‐Dependent Loss of Cannabinoid Receptors and Cannabinoid Receptor‐Activated G Proteins in Rat …

CS Breivogel, SR Childers… - Journal of …, 1999 - Wiley Online Library
: Chronic treatment of rats with ▵ 9 ‐tetrahydrocannabinol (▵ 9 ‐THC) results in tolerance to
its acute behavioral effects. In a previous study, 21‐day ▵ 9 ‐THC treatment in rats …

The functional neuroanatomy of brain cannabinoid receptors

CS Breivogel, SR Childers - Neurobiology of disease, 1998 - Elsevier
The effects of the primary psychoactive constituent of marijuana, Δ 9 -tetrahydrocannabinol,
are mediated by cannabinoid receptors, CB1 and CB2. The CB1 receptors display a unique …

Levels, Metabolism, and Pharmacological Activity of Anandamide in CB1 Cannabinoid Receptor Knockout Mice: Evidence for Non‐CB1, Non‐CB2 Receptor …

V Di Marzo, CS Breivogel, Q Tao… - Journal of …, 2000 - Wiley Online Library
Anandamide [arachidonylethanolamide (AEA)] appears to be an endogenous agonist of brain
cannabinoid receptors (CB 1 ), yet some of the neurobehavioral effects of this compound …

Regional differences in cannabinoid receptor/G-protein coupling in rat brain

CS Breivogel, LJ Sim, SR Childers - Journal of Pharmacology and …, 1997 - ASPET
Cannabinoid receptor activation of G-proteins can be measured by WIN 55212–2-stimulated
[ 35 S]GTPγS binding. Receptor/transducer amplification factors, interpreted as the number …

Cannabis and endogenous cannabinoid systems

SR Childers, CS Breivogel - Drug and alcohol dependence, 1998 - Elsevier
A series of remarkable developments during the last 10 years have provided conclusive
evidence that 9 Ž 9.-tetrahydrocannabinol-THC, the principal psychoactive constituent in …

[HTML][HTML] Cannabinoid receptor agonist efficacy for stimulating [35S] GTPγS binding to rat cerebellar membranes correlates with agonist-induced decreases in GDP …

CS Breivogel, DE Selley, SR Childers - Journal of Biological Chemistry, 1998 - ASBMB
The relationship between GDP and cannabinoid-stimulated [ 35 S]guanosine-5′-O-(3-thiotriphosphate)
([ 35 S]GTPγS) binding was investigated in rat cerebellar membranes. Kinetic …

Activation of cannabinoid receptors in rat brain by WIN 55212-2 produces coupling to multiple G protein α-subunits with different potencies

PL Prather, NA Martin, CS Breivogel… - Molecular pharmacology, 2000 - ASPET
Previous studies had shown that the amplification factors for cannabinoid receptors, defined
as the number of total G proteins activated per occupied receptor, differs between several …

Sensitivity to Δ9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2−/− mice

CS Breivogel, JM Lambert, S Gerfin… - Behavioural …, 2008 - journals.lww.com
Little is known about the roles of β-arrestins in the regulation of brain CB 1 cannabinoid
receptors. This study investigated the role of β-arrestin2 in cannabinoid behavioral effects using β…