Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs
JA Marwick, PA Kirkham, CS Stevenson… - American journal of …, 2004 - atsjournals.org
Cigarette smoke–triggered inflammation is considered to play a central role in the development
of chronic obstructive pulmonary disease by a mechanism that may involve enhanced …
of chronic obstructive pulmonary disease by a mechanism that may involve enhanced …
Inhibition of PI3Kδ restores glucocorticoid function in smoking-induced airway inflammation in mice
JA Marwick, G Caramori, CS Stevenson… - American journal of …, 2009 - atsjournals.org
Rationale: There is an increasing prevalence of reduced responsiveness to glucocorticoid
therapy in severe asthma and chronic obstructive pulmonary disease (COPD). The molecular …
therapy in severe asthma and chronic obstructive pulmonary disease (COPD). The molecular …
The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore
CS Stevenson, EA Capper, AK Roshak… - … of Pharmacology and …, 2002 - ASPET
Marine natural products provide a rich source of chemical diversity that can be used to design
and develop new, potentially useful therapeutic agents. We report here that scytonemin, a …
and develop new, potentially useful therapeutic agents. We report here that scytonemin, a …
[HTML][HTML] Bleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: a model for “active” disease
…, DC Budd, JS Fine, CMT Bauer, CS Stevenson - PloS one, 2013 - journals.plos.org
The preclinical model of bleomycin-induced lung fibrosis, used to investigate mechanisms
related to idiopathic pulmonary fibrosis (IPF), has incorrectly predicted efficacy for several …
related to idiopathic pulmonary fibrosis (IPF), has incorrectly predicted efficacy for several …
[HTML][HTML] Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosis
…, AM Holmes, C Kitson, CS Stevenson… - The American journal of …, 2013 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease of high unmet medical need.
Although bromodomain (Brd) and extra terminal domain isoforms have recently been …
Although bromodomain (Brd) and extra terminal domain isoforms have recently been …
Moving towards a new generation of animal models for asthma and COPD with improved clinical relevance
CS Stevenson, MA Birrell - Pharmacology & therapeutics, 2011 - Elsevier
Asthma and chronic obstructive pulmonary disease (COPD) are complex inflammatory airway
diseases characterised by airflow obstruction that remain leading causes of hospitalization …
diseases characterised by airflow obstruction that remain leading causes of hospitalization …
[HTML][HTML] P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smoke
S Eltom, CS Stevenson, J Rastrick, N Dale… - PLoS one, 2011 - journals.plos.org
Chronic Obstructive Pulmonary Disease (COPD) is a cigarette smoke (CS)-driven inflammatory
airway disease with an increasing global prevalence. Currently there is no effective …
airway disease with an increasing global prevalence. Currently there is no effective …
The single-cell immunogenomic landscape of B and plasma cells in early-stage lung adenocarcinoma
…, II Wistuba, CS Stevenson, A Spira, S Shalapour… - Cancer discovery, 2022 - AACR
While TIBs are highly enriched in LUADs, they are poorly characterized. This study provides
a much-needed understanding of the transcriptional, clonotypic states and phenotypes of …
a much-needed understanding of the transcriptional, clonotypic states and phenotypes of …
IL-17A and the promotion of neutrophilia in acute exacerbation of chronic obstructive pulmonary disease
…, P Shen, D Bowdish, CS Stevenson… - American journal of …, 2015 - atsjournals.org
Rationale: Nontypeable Haemophilus influenzae (NTHi) causes acute exacerbation of chronic
obstructive pulmonary disease (AECOPD). IL-17A is central for neutrophilic inflammation …
obstructive pulmonary disease (AECOPD). IL-17A is central for neutrophilic inflammation …
Resolving the spatial and cellular architecture of lung adenocarcinoma by multiregion single-cell sequencing
…, SM Dubinett, J Fujimoto, II Wistuba, CS Stevenson… - Cancer discovery, 2021 - AACR
The geospatial ecosystem of the peripheral lung and early-stage LUAD is not known. Our
multiregion single-cell sequencing analyses unravel cell populations, states, and phenotypes …
multiregion single-cell sequencing analyses unravel cell populations, states, and phenotypes …