The differential interactions of peroxisome proliferator-activated receptor γ ligands with Tyr473 is a physical basis for their unique biological activities
M Einstein, TE Akiyama, GA Castriota, CF Wang… - Molecular …, 2008 - ASPET
Despite their proven antidiabetic efficacy, widespread use of peroxisome proliferator-activated
receptor (PPAR)γ agonists has been limited by adverse cardiovascular effects. To …
receptor (PPAR)γ agonists has been limited by adverse cardiovascular effects. To …
Selective PPARγ modulators with improved pharmacological profiles
…, L Colwell, C Liu, M Wu, CF Wang… - Bioorganic & medicinal …, 2005 - Elsevier
A series of metabolically robust N-benzyl-indole selective PPARγ modulators with either a 3-benzoyl
or 3-benzisoxazoyl moiety have been identified. In vitro, these compounds are …
or 3-benzisoxazoyl moiety have been identified. In vitro, these compounds are …
Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity
…, TM Kelly, P Mazur, CM Thompson, CF Wang… - Bioorganic & medicinal …, 2005 - Elsevier
A novel series of selective ligands for the human glucocorticoid receptor is described.
Structure–activity studies focused on variation of B-ring size, ketal ring size, and ketal substitution. …
Structure–activity studies focused on variation of B-ring size, ketal ring size, and ketal substitution. …
Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion
…, CS Louden, BL Lopez, TA Christopher, C Wang… - Circulation, 1999 - Am Heart Assoc
Background—Activation of p38 mitogen-activated protein kinase (MAPK) plays an important
role in apoptotic cell death. The role of p38 MAPK in myocardial injury caused by ischemia/…
role in apoptotic cell death. The role of p38 MAPK in myocardial injury caused by ischemia/…
Inhibition of extracellular signal–regulated kinase enhances ischemia/reoxygenation–induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion …
… Adding to the complexity of the matter, Wang et al 13 reported that activation of JNK alone
by transfection of cultured rat neonatal cardiomyocytes with MKK7, an upstream activator of …
by transfection of cultured rat neonatal cardiomyocytes with MKK7, an upstream activator of …
Strengthening/retrofitting techniques on unreinforced masonry structure/element subjected to seismic loads: A literature review
C Wang, V Sarhosis, N Nikitas - Open Construction and …, 2018 - eprints.whiterose.ac.uk
Masonry structures commonly exist in reality and still are popular all over the world. It has
been reported and studied that these buildings are vulnerable to strong external loadings …
been reported and studied that these buildings are vulnerable to strong external loadings …
[HTML][HTML] Extracellular signal-regulated kinase plays an essential role in hypertrophic agonists, endothelin-1 and phenylephrine-induced cardiomyocyte hypertrophy
TL Yue, JL Gu, C Wang, AA Parsons… - Journal of Biological …, 2000 - ASBMB
The extracellular signal-regulated kinase (ERK) pathway is activated by hypertrophic stimuli
in cardiomyocytes. However, whether ERK plays an essential role or is implicated in all …
in cardiomyocytes. However, whether ERK plays an essential role or is implicated in all …
[HTML][HTML] Mechanical performance and microstructure of ultra-high-performance concrete modified by calcium sulfoaluminate cement
M Song, C Wang, Y Cui, Q Li, Z Gao - Advances in Civil Engineering, 2021 - hindawi.com
High autogenous shrinkage property is one of the disadvantages of ultra-high-performance
concrete (UHPC), which may induce early age cracking and threaten the safety of concrete …
concrete (UHPC), which may induce early age cracking and threaten the safety of concrete …
[HTML][HTML] Gain deeper insights into traditional Chinese medicines using multidimensional chromatography combined with chemometric approaches
X Yang, P Zeng, J Wen, C Wang, L Yao, M He - Chinese Herbal Medicines, 2023 - Elsevier
Traditional Chinese medicines (TCMs) possess a rich historical background, unique
theoretical framework, remarkable therapeutic efficacy, and abundant resources. However, the …
theoretical framework, remarkable therapeutic efficacy, and abundant resources. However, the …
Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein
CJ Li, DJ Friedman, C Wang, V Metelev, AB Pardee - Science, 1995 - science.org
Infection by human immunodeficiency virus-type 1 (HIV-1) is typified by the progressive
depletion of CD4 T lymphocytes and deterioration of immune function in most patients. A central …
depletion of CD4 T lymphocytes and deterioration of immune function in most patients. A central …