[HTML][HTML] Ca2+-independent smooth muscle contraction: a novel function for integrin-linked kinase

JT Deng, JE Van Lierop, C Sutherland… - Journal of Biological …, 2001 - ASBMB
Smooth muscle contraction follows an increase in cytosolic Ca 2+ concentration, activation
of myosin light chain kinase, and phosphorylation of the 20-kDa light chain of myosin at Ser …

Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+ sensitization: Rho-associated kinase …

DP Wilson, M Susnjar, E Kiss, C Sutherland… - Biochemical …, 2005 - portlandpress.com
The signal transduction pathway whereby the TxA 2 (thromboxane A 2 ) mimetic U-46619
activates vascular smooth muscle contraction was investigated in de-endothelialized rat …

Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure

…, MT Jiang, M Zhao, D Yang, C Sutherland… - Circulation …, 2005 - Am Heart Assoc
Hyperphosphorylation of the cardiac Ca 2+ release channel (ryanodine receptor, RyR2) by
protein kinase A (PKA) at serine-2808 has been proposed to be a key mechanism …

Protein Kinase A Phosphorylation at Serine-2808 of the Cardiac Ca2+-Release Channel (Ryanodine Receptor) Does Not Dissociate 12.6-kDa FK506-Binding …

B Xiao, C Sutherland, MP Walsh, SRW Chen - Circulation research, 2004 - Am Heart Assoc
Dissociation of FKBP12.6 from the cardiac Ca 2+ -release channel (RyR2) as a consequence
of protein kinase A (PKA) hyperphosphorylation of RyR2 at a single amino acid residue, …

Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase

JT Deng, C Sutherland, DL Brautigan, M Eto… - Biochemical …, 2002 - portlandpress.com
Integrin-linked kinase (ILK) has been implicated in Ca 2+ - independent contraction of
smooth muscle via its ability to phosphorylate myosin. We investigated the possibility that this …

Integrin-linked kinase is responsible for Ca2+-independent myosin diphosphorylation and contraction of vascular smooth muscle

DP Wilson, C Sutherland, MA Borman… - Biochemical …, 2005 - portlandpress.com
Smooth muscle contraction is activated by phosphorylation at Ser-19 of LC 20 (the 20 kDa
light chains of myosin II) by Ca 2+ /calmodulin-dependent MLCK (myosin light-chain kinase). …

Differential regulation of Ca2+/calmodulin-dependent enzymes by plant calmodulin isoforms and free Ca2+ concentration

…, JE VAN LIEROP, C SUTHERLAND… - Biochemical …, 2000 - portlandpress.com
Multiple calmodulin (CaM) isoforms are expressed in plants, but their biochemical characteristics
are not well resolved. Here we show the differential regulation exhibited by two soya …

[HTML][HTML] Cross-talk between Rho-associated kinase and cyclic nucleotide-dependent kinase signaling pathways in the regulation of smooth muscle myosin light chain …

ME Grassie, C Sutherland, A Ulke-Lemée… - Journal of Biological …, 2012 - ASBMB
Ca 2+ sensitization of smooth muscle contraction depends upon the activities of protein kinases,
including Rho-associated kinase, that phosphorylate the myosin phosphatase targeting …

Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor

…, BJ Zieba, AV Somlyo, C Sutherland… - ACS chemical …, 2013 - ACS Publications
DAPK1 and ZIPK (also called DAPK3) are closely related serine/threonine protein kinases
that regulate programmed cell death and phosphorylation of non-muscle and smooth muscle …

[HTML][HTML] Ca2+ activation of smooth muscle contraction: evidence for the involvement of calmodulin that is bound to the Triton-insoluble fraction even in the absence of …

DP Wilson, C Sutherland, MP Walsh - Journal of Biological Chemistry, 2002 - ASBMB
Smooth muscle contraction is activated by phosphorylation of the 20-kDa light chains of
myosin catalyzed by Ca 2+ /calmodulin (CaM)-dependent myosin light chain kinase (MLCK). …