Epigallocathechin-3 gallate selectively inhibits the PDGF-BB–induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits …
HY Ahn, KR Hadizadeh, C Seul, YP Yun… - Molecular biology of …, 1999 - Am Soc Cell Biol
Enhanced activity of receptor tyrosine kinases such as the PDGF β-receptor and EGF
receptor has been implicated as a contributing factor in the development of malignant and …
receptor has been implicated as a contributing factor in the development of malignant and …
Green tea compounds inhibit tyrosine phosphorylation of PDGF β‐receptor and transformation of A172 human glioblastoma
A Sachinidis, C Seul, S Seewald, HY Ahn, Y Ko… - FEBS …, 2000 - Wiley Online Library
The effect of the green tea compounds 2‐(3,4‐dihydroxyphenyl)‐3,4‐dihydro‐2H‐1‐benzopyran‐3,5,7‐triol
(catechin), epicathechin (EC), epigallocathechin‐3 gallate (EGCG), …
(catechin), epicathechin (EC), epigallocathechin‐3 gallate (EGCG), …
Evidence that lipoproteins are carriers of bioactive factors
…, I Gouni-Berthold, U Schmitz, C Seul… - … , and vascular biology, 1999 - Am Heart Assoc
We recently demonstrated that the mitogenic effect of LDL (100 μg/mL) as well as its early
intracellular signaling pathway are mediated by a pertussis-toxin (PTX)-sensitive G i protein-…
intracellular signaling pathway are mediated by a pertussis-toxin (PTX)-sensitive G i protein-…
Inhibition of the PDGF beta-receptor tyrosine phosphorylation and its downstream intracellular signal transduction pathway in rat and human vascular smooth muscle …
A Sachinidis, RA Skach, C Seul, YON Ko… - … : official publication of …, 2002 - europepmc.org
Abnormal proliferation of vascular smooth muscle cells (VSMC) as well as the platelet-derived
growth factor (PDGF) plays an important role in the development of proliferative …
growth factor (PDGF) plays an important role in the development of proliferative …
Lysophosphatidic acid and intracellular signalling in vascular smooth muscle cells
S Seewald, A Sachinidis, R Düsing, Y Ko, C Seul… - Atherosclerosis, 1997 - Elsevier
Growth of vascular smooth muscle cells (VSMC) plays an important role in the pathogenesis
of atherosclerosis and hypertension. Lysophosphatidic acid (LPA), a natural phospholipid is …
of atherosclerosis and hypertension. Lysophosphatidic acid (LPA), a natural phospholipid is …
Gangliosides GM1 and GM2 induce vascular smooth muscle cell proliferation via extracellular signal-regulated kinase 1/2 pathway
I Gouni-Berthold, C Seul, Y Ko, J Hescheler… - …, 2001 - Am Heart Assoc
Gangliosides, sialic acid-containing glycophospholipids, accumulate in atherosclerotic
vessels and appear to regulate the proliferation of various cell types. Furthermore, vascular …
vessels and appear to regulate the proliferation of various cell types. Furthermore, vascular …
Troglitazone and rosiglitazone induce apoptosis of vascular smooth muscle cells through an extracellular signal-regulated kinase-independent pathway
…, HK Berthold, AA Weber, Y Ko, C Seul… - Naunyn-Schmiedeberg's …, 2001 - Springer
Recent evidence suggests that apoptosis may be involved in the control of vascular smooth
muscle cell (VSMC) number in atherosclerotic lesions. The peroxisome proliferator-activated …
muscle cell (VSMC) number in atherosclerotic lesions. The peroxisome proliferator-activated …
Lysophosphatidic acid stimulates protein kinase C isoforms α, β, ε, and ζ in a pertussis toxin sensitive pathway in vascular smooth muscle cells
S Seewald, U Schmitz, C Seul, Y Ko… - American journal of …, 1999 - academic.oup.com
The natural phospholipid lysophosphatidic acid (LPA) has been characterized as an
important vascular smooth muscle cell (VSMC) mitogen whose effects are mainly mediated by …
important vascular smooth muscle cell (VSMC) mitogen whose effects are mainly mediated by …
The growth-promoting effect of low-density lipoprotein may be mediated by a pertussis toxin-sensitive mitogen-activated protein kinase pathway
A Sachinidis, S Seewald, P Epping, C Seul, Y Ko… - Molecular …, 1997 - ASPET
Low-density lipoprotein (LDL) is known to be a mitogenic factor for vascular smooth muscle
cells (VSMCs), fibroblasts, and endothelial cells. In the current study, we describe possible …
cells (VSMCs), fibroblasts, and endothelial cells. In the current study, we describe possible …
Biotransformation of glyceryl trinitrate by blood platelets as compared to vascular smooth muscle cells
AA Weber, T Neuhaus, C Seul, R Düsing… - European journal of …, 1996 - Elsevier
The present study investigated the metabolism of glyceryl trinitrate by washed human platelets
as compared to that by rat vascular smooth muscle cells. Possible changes in metabolism …
as compared to that by rat vascular smooth muscle cells. Possible changes in metabolism …