Functional selectivity of G protein–coupled receptor (GPCR) ligands toward different
downstream signals has recently emerged as a general hallmark of this receptor class. However, …

Hypersecretion of norepinephrine (NE) and angiotensin II (AngII) is a hallmark of major
prevalent cardiovascular diseases that contribute to cardiac pathophysiology and morbidity. …

Hyperactivity of the renin–angiotensin–aldosterone system through the angiotensin II (Ang II)/Ang
II type 1 receptor (AT1-R) axis constitutes a hallmark of hypertension. Recent findings …

Vascular calcification is an important risk factor for cardiovascular (CV) mortality in patients
with chronic kidney disease (CKD). It is also a complex process involving osteochondrogenic …

Cell surface G protein-coupled receptors (GPCRs) drive numerous signaling pathways
involved in the regulation of a broad range of physiologic processes. Today, they represent the …

Chronic kidney disease (CKD) is a prevalent cause of morbidity and mortality worldwide. A
hallmark of CKD progression is renal fibrosis characterized by excessive accumulation of …

The family of α2-adrenergic receptors (α2-ARs) comprises three subtypes which are each
endowed with specific functions. α2-agonists and α2-antagonists are part of the clinician …

Mechanisms underlying the onset and progression of nephropathy in diabetic patients are
not fully elucidated. Deregulation of proteolytic systems is a known path leading to disease …

Background We recently demonstrated that chronic dietary exposure to a mixture of pesticides
at low-doses induced sexually dimorphic obesogenic and diabetogenic effects in adult …

Although cardiovascular disease (CVD) is the leading cause of morbimortality worldwide,
promising new drug candidates are lacking. We compared the arterial high-resolution …