Although practiced clinically for more than 40 years, the use of hematopoietic stem cell (HSC)
transplants remains limited by the ability to expand these cells ex vivo. An unbiased …

Inflammatory signaling plays a key role in tumor progression, and the pleiotropic cytokine
interleukin-6 (IL-6) is an important mediator of protumorigenic properties. Activation of the aryl …

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor involved in
the regulation of multiple cellular pathways, such as xenobiotic metabolism and Th17 cell …

Malignant cells exhibit aerobic glycolysis (the Warburg effect) and become dependent on
de novo lipogenesis, which sustains rapid proliferation and resistance to cellular stress. The …

The aryl hydrocarbon receptor (AHR) is a ligand-inducible transcription factor that displays
interspecies differences with the human and mouse AHR C-terminal region sequences …

Fluorescent proteins are widely used to study molecular and cellular events, yet this traditionally
relies on delivery of excitation light, which can trigger autofluorescence, photoxicity, and …

The human aryl hydrocarbon receptor (hAHR) and mouse aryl hydrocarbon receptor (mAHR
b ) share limited (58%) transactivation domain (TAD) sequence identity. Compared to the …

The concept of selective receptor modulators has been established for the nuclear steroid
hormone receptors. Such selective modulators have been used therapeutically with great …

Repression of the nuclear factor-κB (NF-κB) pathway has been extensively researched
because of its pivotal role in inflammation. We investigated the potential of the aryl hydrocarbon …

Objective Non-alcoholic steatohepatitis (NASH) is characterized by hepatic steatosis,
inflammation and fibrosis. There are currently no targeted therapies for NASH. We developed a …