User profiles for Corey R. Hopkins

Corey R. Hopkins

University of Nebraska Medical Center
Verified email at unmc.edu
Cited by 6165

In Vivo Structure−Activity Relationship Study of Dorsomorphin Analogues Identifies Selective VEGF and BMP Inhibitors

…, RN Daniels, PR Gentry, CR Hopkins… - ACS chemical …, 2010 - ACS Publications
The therapeutic potential of small molecule signaling inhibitors is often limited by off-target
effects. Recently, in a screen for compounds that perturb the zebrafish embryonic …

Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery

BJ Melancon, CR Hopkins, MR Wood… - Journal of medicinal …, 2012 - ACS Publications
(PAMs), which potentiate GABAA receptor response, and negative allosteric modulators (NAMs),
which decrease channel activity and modulate the ability of these GABAergic receptors …

[HTML][HTML] Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels

…, JM Salovich, CD Weaver, CR Hopkins… - Journal of Biological …, 2011 - ASBMB
Transient receptor potential canonical (TRPC) channels are Ca 2+ -permeable nonselective
cation channels implicated in diverse physiological functions, including smooth muscle …

[HTML][HTML] Advancing biological understanding and therapeutics discovery with small-molecule probes

…, B Edwards, TI Oprea, PJ Conn, CR Hopkins… - Cell, 2015 - cell.com
Small-molecule probes can illuminate biological processes and aid in the assessment of
emerging therapeutic targets by perturbing biological systems in a manner distinct from other …

Practical strategies and concepts in GPCR allosteric modulator discovery: recent advances with metabotropic glutamate receptors

CW Lindsley, KA Emmitte, CR Hopkins… - Chemical …, 2016 - ACS Publications
Allosteric modulation of GPCRs has initiated a new era of basic and translational discovery,
filled with therapeutic promise yet fraught with caveats. Allosteric ligands stabilize unique …

“Molecular switches” on mGluR allosteric ligands that modulate modes of pharmacology

MR Wood, CR Hopkins, JT Brogan, PJ Conn… - Biochemistry, 2011 - ACS Publications
G-Protein-coupled receptors (GPCRs) represent the largest class of drug targets, accounting
for more than 40% of marketed drugs; however, discovery efforts for many GPCRs have …

[HTML][HTML] Inhibition of the TRPC5 ion channel protects the kidney filter

…, H Wallentin, H Heid, CR Hopkins… - The Journal of …, 2013 - Am Soc Clin Investig
An intact kidney filter is vital to retention of essential proteins in the blood and removal of
waste from the body. Damage to the filtration barrier results in albumin loss in the urine, a …

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

…, AC Johnson, ES Lander, MR Garrett, CR Hopkins… - Science, 2017 - science.org
Progressive kidney diseases are often associated with scarring of the kidney’s filtration unit,
a condition called focal segmental glomerulosclerosis (FSGS). This scarring is due to loss of …

DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction

…, AA Aboud, CR Hopkins, R Chamberlin… - ACS chemical …, 2012 - ACS Publications
Recent successes in deriving human-induced pluripotent stem cells (hiPSCs) allow for the
possibility of studying human neurons derived from patients with neurological diseases. …

The discovery and characterization of ML218: a novel, centrally active T-type calcium channel inhibitor with robust effects in STN neurons and in a rodent model of …

…, CK Jones, JS Daniels, CR Hopkins… - ACS chemical …, 2011 - ACS Publications
T-Type Ca 2+ channel inhibitors hold tremendous therapeutic potential for the treatment of
pain, epilepsy, sleep disorders, essential tremor, and other neurological disorders; however, …