Although class AG protein−coupled receptors (GPCRs) can function as monomers, many of
them form dimers and oligomers, but the mechanisms and functional relevance of such …

G protein–coupled receptors (GPCRs) are regulated by complex molecular mechanisms, both
in physiologic and pathologic conditions, and their signaling can be intricate. Many factors …

G protein–coupled receptors (GPCRs) are biologic switches that transduce extracellular
stimuli into intracellular responses in the cell. Temporally resolving GPCR transduction …

Antinociceptive pathways are activated in the periphery in inflammatory pain, for instance
resolvins and opioid peptides. Resolvins are biosynthesized from omega-3 polyunsaturated …

The serine/threonine protein kinase AKT1 is a downstream target of the chemokine receptor
4 (CXCR4), and both proteins play a central role in the modulation of diverse cellular …

The CXCL12 chemokine receptor CXCR4 belongs to the GPCR superfamily and is often
overexpressed in cancer, being involved in tumor progression and metastasis. How CXCR4 …

The CXC chemokine receptor 4 (CXCR4) and the atypical chemokine receptor 3 (ACKR3)
are seven transmembrane receptors that are involved in numerous pathologies, including …

Atypical chemokine receptor 3 (ACKR3), formerly referred to as CXCR7, is considered to be
an interesting drug target. In this study, we report on the synthesis, pharmacological …

In this thesis, a 3D Ultrashort echo time (3D-UTE) sequence was introduced in the Self-gated
Non-Contrast-Enhanced Functional Lung Imaging (SENCEFUL) framework. The sequence …

The olfactory epithelium (OE) possesses unique lifelong neuroregenerative capacities and
undergoes constitutive neurogenesis throughout mammalian lifespan. Two populations of …