Increase in rat brain acetylcholine induced by choline or deanol

DR Haubrich, PFL Wang, DE Clody, PW Wedeking - Life sciences, 1975 - Elsevier
Administration of choline chloride, deanol, or Deaner ® to rats subsequently killed by microwave
irradiation caused an increase in the concentration of both choline and acetylcholine in …

Choline dehydrogenase: assay, properties and inhibitors

DR Haubrich, NH Gerber - Biochemical pharmacology, 1981 - Elsevier
Although choline has proven useful in the treatment of neurological disorders, its duration of
action is limited by its rapid rate of metabolism. In order to evaluate the role of choline …

Pharmacology of pravadoline: a new analgesic agent.

DR Haubrich, SJ Ward, E Baizman, MR Bell… - … of Pharmacology and …, 1990 - ASPET
Pravadoline is a new chemical entity with analgesic activity in humans. This report describes
the pharmacology of pravadoline and compares the activity of pravadoline with that of two …

Distribution and metabolism of intravenously administered choline [methyl-3-H] and synthesis in vivo of acetylcholine in various tissues of guinea pigs.

DR Haubrich, PF Wang, PW Wedeking - Journal of Pharmacology and …, 1975 - ASPET
The biosynthesis of acetylcholine and the fate of intravenously administered choline [methyl-
3-H] were studied in guinea pigs anesthetized with pentobarbital. Choline and …

Increase in tissue concentration of acetylcholine in guinea pigs in vivo induced by administration of choline

DR Haubrich, PW Wedeking, PFL Wang - Life sciences, 1974 - Elsevier
Administration of choline chloride (200 μmoles/kg) intravenously to guinea pigs caused an
increase in the concentrations of choline and acetylcholine in adrenals, heart, kidneys, lungs, …

. alpha. 2-Adrenergic agonists/antagonists: the synthesis and structure-activity relationships of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines

…, MJ Silbernagel, SJ Ward, DR Haubrich - Journal of medicinal …, 1987 - ACS Publications
HOAc, MeOH; BH3, THF; H2, Pd (C), HC1, EtOH). However, reduction to the alcohol 12a,
acetylation (Ac20, pyridine), and hydrogenolysis of 12b gave the indole-2-acetate 13 in good …

Pharmacological analysis of alpha-2 adrenergic mechanisms in nociception and ataxia.

…, R Ferrari, MH Perrone, DR Haubrich - Journal of Pharmacology …, 1985 - ASPET
In order to assess the involvement of alpha-2 adrenergic receptors in nociception, the in vitro
potencies of seven alpha-2 adrenergic agonists (clonidine, guanabenz, guanfacine, BHT-…

Enzymic radioassay for acetylcholine and choline in brain

WD Reid, DR Haubrich, G Krishna - Analytical Biochemistry, 1971 - Elsevier
This assay for acetylcholine (ACh) or choline in extracts of rat brain involves the isolation of
the choline ester by high-voltage paper electrophoresis, alkaline hydrolysis of ACh to choline…

A simple, sensitive, and specific assay for free choline in plasma

FL Wang, DR Haubrich - Analytical Biochemistry, 1975 - Elsevier
… NaCl (12.5 mM), EDTA (0.1 mM), and choline kinase [prepared as described by Haubrich
and Reid (7)] was added to each tube containing the dried pellet of plasma. Reagent blanks …

Striatal dopamine release and contraversive rotation elicited by intranigrally applied muscimol

GE Martin, DR Haubrich - Nature, 1978 - nature.com
SEVERAL lines of evidence indicate that release of dopamine (DA) within the corpus striatum
mediates turning behaviour in the rat 1,2 . The turning occurs in a direction away from the …