User profiles for D. R. Laver

Derek Laver

Verified email at newcastle.edu.au
Cited by 6347

[HTML][HTML] Calsequestrin and the calcium release channel of skeletal and cardiac muscle

NA Beard, DR Laver, AF Dulhunty - Progress in biophysics and molecular …, 2004 - Elsevier
Calsequestrin is by far the most abundant Ca 2+ -binding protein in the sarcoplasmic
reticulum (SR) of skeletal and cardiac muscle. It allows the Ca 2+ required for contraction to be …

[HTML][HTML] Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sites

DR Laver - Biophysical journal, 2007 - cell.com
The free [Ca 2+ ] in endoplasmic/sarcoplasmic reticulum Ca 2+ stores regulates excitability
of Ca 2+ release by stimulating the Ca 2+ release channels. Just how the stored Ca 2+ …

Generation and propagation of gastric slow waves

DF Van Helden, DR Laver… - Clinical and …, 2010 - Wiley Online Library
Mechanisms underlying the generation and propagation of gastrointestinal slow wave
depolarizations have long been controversial. The present review aims to collate present …

Magnesium inhibition of ryanodine-receptor calcium channels: evidence for two independent mechanisms

DR Laver, TM Baynes, AF Dulhunty - The Journal of membrane biology, 1997 - Springer
… We wish to thank Heather Domaschenz and Lin Roden for their assistance with the experiments
and Lin Roden and Dr. Pauline Junankar for supplying SR vesicles. We also thank Dr. …

[HTML][HTML] Calsequestrin is an inhibitor of skeletal muscle ryanodine receptor calcium release channels

NA Beard, MM Sakowska, AF Dulhunty, DR Laver - Biophysical journal, 2002 - cell.com
We provide novel evidence that the sarcoplasmic reticulum calcium binding protein,
calsequestrin, inhibits native ryanodine receptor calcium release channel activity. Calsequestrin …

Cytoplasmic Ca2+ inhibits the ryanodine receptor from cardiac muscle

DR Laver, LD Roden, GP Ahern, KR Eager… - The Journal of …, 1995 - Springer
Ca 2+ -dependent inhibition of native and isolated ryanodine receptor (RyR) calcium release
channels from sheep heart and rabbit skeletal muscle was investigated using the lipid …

[PDF][PDF] Mammalian TRP ion channels are insensitive to membrane stretch

…, JF Cordero-Morales, V Vasquez, DR Laver… - Biophysical …, 2020 - cell.com
TRP channels of the transient receptor potential ion channel superfamily play an important
role in a wide variety of mechanosensory processes, including touch sensation, pain, blood …

[PDF][PDF] Control of sarcoplasmic reticulum Ca2+ release by stochastic RyR gating within a 3D model of the cardiac dyad and importance of induction decay for CICR …

MB Cannell, CHT Kong, MS Imtiaz, DR Laver - Biophysical journal, 2013 - cell.com
… MB Cannell and DR Laver contributed equally to this work. … Some of the rat data values
have been replotted from Laver et al. (24). (C) Cytoplasmic [Ca2þ] dependence of sheep RyR …

[HTML][HTML] Regulation of ryanodine receptors by calsequestrin: effect of high luminal Ca2+ and phosphorylation

…, MG Casarotto, L Wei, M Varsányi, DR Laver… - Biophysical journal, 2005 - cell.com
Calsequestrin, the major calcium sequestering protein in the sarcoplasmic reticulum of muscle,
forms a quaternary complex with the ryanodine receptor calcium release channel and the …

RYR2 channel inhibition is the principal mechanism of flecainide action in CPVT

…, AN Smith, SM Batiste, JN Johnston, DR Laver… - Circulation …, 2021 - Am Heart Assoc
… Institute (DR Laver). Ca wave measurements were performed using the VUMC Cell Imaging
Shared Resource (supported by NIH grants CA68485, DK20593, DK58404, DK59637, and …