User profiles for D. R. Laver
Derek LaverVerified email at newcastle.edu.au Cited by 6347 |
[HTML][HTML] Calsequestrin and the calcium release channel of skeletal and cardiac muscle
Calsequestrin is by far the most abundant Ca 2+ -binding protein in the sarcoplasmic
reticulum (SR) of skeletal and cardiac muscle. It allows the Ca 2+ required for contraction to be …
reticulum (SR) of skeletal and cardiac muscle. It allows the Ca 2+ required for contraction to be …
[HTML][HTML] Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sites
DR Laver - Biophysical journal, 2007 - cell.com
The free [Ca 2+ ] in endoplasmic/sarcoplasmic reticulum Ca 2+ stores regulates excitability
of Ca 2+ release by stimulating the Ca 2+ release channels. Just how the stored Ca 2+ …
of Ca 2+ release by stimulating the Ca 2+ release channels. Just how the stored Ca 2+ …
Generation and propagation of gastric slow waves
DF Van Helden, DR Laver… - Clinical and …, 2010 - Wiley Online Library
Mechanisms underlying the generation and propagation of gastrointestinal slow wave
depolarizations have long been controversial. The present review aims to collate present …
depolarizations have long been controversial. The present review aims to collate present …
Magnesium inhibition of ryanodine-receptor calcium channels: evidence for two independent mechanisms
… We wish to thank Heather Domaschenz and Lin Roden for their assistance with the experiments
and Lin Roden and Dr. Pauline Junankar for supplying SR vesicles. We also thank Dr. …
and Lin Roden and Dr. Pauline Junankar for supplying SR vesicles. We also thank Dr. …
[HTML][HTML] Calsequestrin is an inhibitor of skeletal muscle ryanodine receptor calcium release channels
We provide novel evidence that the sarcoplasmic reticulum calcium binding protein,
calsequestrin, inhibits native ryanodine receptor calcium release channel activity. Calsequestrin …
calsequestrin, inhibits native ryanodine receptor calcium release channel activity. Calsequestrin …
Cytoplasmic Ca2+ inhibits the ryanodine receptor from cardiac muscle
Ca 2+ -dependent inhibition of native and isolated ryanodine receptor (RyR) calcium release
channels from sheep heart and rabbit skeletal muscle was investigated using the lipid …
channels from sheep heart and rabbit skeletal muscle was investigated using the lipid …
[PDF][PDF] Mammalian TRP ion channels are insensitive to membrane stretch
TRP channels of the transient receptor potential ion channel superfamily play an important
role in a wide variety of mechanosensory processes, including touch sensation, pain, blood …
role in a wide variety of mechanosensory processes, including touch sensation, pain, blood …
[PDF][PDF] Control of sarcoplasmic reticulum Ca2+ release by stochastic RyR gating within a 3D model of the cardiac dyad and importance of induction decay for CICR …
… MB Cannell and DR Laver contributed equally to this work. … Some of the rat data values
have been replotted from Laver et al. (24). (C) Cytoplasmic [Ca2þ] dependence of sheep RyR …
have been replotted from Laver et al. (24). (C) Cytoplasmic [Ca2þ] dependence of sheep RyR …
[HTML][HTML] Regulation of ryanodine receptors by calsequestrin: effect of high luminal Ca2+ and phosphorylation
Calsequestrin, the major calcium sequestering protein in the sarcoplasmic reticulum of muscle,
forms a quaternary complex with the ryanodine receptor calcium release channel and the …
forms a quaternary complex with the ryanodine receptor calcium release channel and the …
RYR2 channel inhibition is the principal mechanism of flecainide action in CPVT
… Institute (DR Laver). Ca wave measurements were performed using the VUMC Cell Imaging
Shared Resource (supported by NIH grants CA68485, DK20593, DK58404, DK59637, and …
Shared Resource (supported by NIH grants CA68485, DK20593, DK58404, DK59637, and …