The blood–brain barrier prevents the entry of many potentially therapeutic peptide drugs to
the brain. Glycosylation has shown potential as a methodology for improving delivery to the …

Cannabinoid drugs differ in their rank order of potency to produce analgesia versus other
central nervous system effects. We propose that these differences are due to unique agonist-…

Delta opioid receptor (DOR) agonists are attractive potential analgesics, since these compounds
exhibit strong antinociceptive activity with relatively few side effects. In the past decade, …

On the basis of the structure−activity relationships of δ-opioid-selective peptide ligands and
on a model of the proposed bioactive conformation for a potent and selective, …

Adenylyl cyclase (AC) superactivation is thought to play an important role in opioid tolerance,
dependence, and withdrawal. In the present study, we investigated the involvement of …

The identification of adenylyl cyclase isoenzymes in mammalian host cells is important for the
interpretation of data obtained from cell lines heterologously expressing G-protein coupled …

Superpotent and highly δ-opioid receptor selective cyclic peptides of the general formula H-Tyr-c[d-Pen-Gly-Phe(p-X)-Pen]-Phe-OH
(where X = hydrogen or halogen) have been …

The synthesis and biological activity of two fragments of the very potent opioid peptide
biphalin, showed that Tyr-D-Ala-Gly-Phe-NH-NH<-Phe is the minimal fragment necessary to …

Chronic δ-opioid receptor agonist treatment of Chinese hamster ovary (CHO) cells stably
expressing the human δ-opioid receptor (hDOR/CHO) leads to increased cAMP formation after …

In the present study, we replaced the third extracellular loop of the human delta-opioid receptor
with that of the human mu-opioid receptor. A modified polymerase chain reaction overlap …