Asthma is characterised by chronic airway inflammation, airway obstruction and hyper-responsiveness.
The inflammatory cascade in asthma comprises a complex interplay of genetic …

Here we describe the pharmacologic properties of a series of clinically relevant chemoattractant
receptor-homologous molecules expressed on T-helper type 2 (CRTh2) receptor …

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel
are established as the primary causative factor in the devastating lung disease cystic fibrosis (…

High throughput screening identified a 7-azaindole-3-acetic acid scaffold as a novel CRTh2
receptor antagonist chemotype, which could be optimised to furnish a highly selective …

Further optimization of an initial DP 2 receptor antagonist clinical candidate NVP-QAV680
led to the discovery of a follow-up molecule 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl…

Ligand binding to membrane proteins may be significantly influenced by the interaction of
ligands with the membrane. In particular, the microscopic ligand concentration within the …

Pseudoephedrine serves as a dual purpose chiral auxiliary and protecting group in the
synthesis of the novel orally active renin inhibitor CGP60536B.

The synthesis of a series of indacaterol analogues in which each of the three structural regions
of indacaterol are modified in a systematic manner is described. Evaluation of the affinity …

Human type 2 cytotoxic T (Tc2) cells are enriched in severe eosinophilic asthma and can
contribute to airway eosinophilia. PGD 2 and its receptor PGD 2 receptor 2 (DP2) play …

We thank Drs Daniel Rotrosen and Alkis Togias from the National Institute of Allergy and
Infectious Diseases for their review of the manuscript, Ms Monica Campbell from the University …