User profiles for David F Wiemer
DAVID F. WIEMERF. Wendell Miller Professor of Chemistry & Professor of Pharmacology Verified email at uiowa.edu Cited by 8106 |
Prodrugs of phosphonates and phosphates: crossing the membrane barrier
A substantial portion of metabolism involves transformation of phosphate esters, including
pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and …
pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and …
Lucibufagins: Defensive steroids from the fireflies Photinus ignitus and P. marginellus (Coleoptera: Lampyridae)
T Eisner, DF Wiemer, LRW Haynes… - Proceedings of the …, 1978 - National Acad Sciences
Feeding tests with thrushes (Hylocichla spp.) led to the isolation of three novel steroid
pyrones from fireflies (Photinus ignitus and P. marginellus) responsible, in part at least, for the …
pyrones from fireflies (Photinus ignitus and P. marginellus) responsible, in part at least, for the …
Synthesis of nonracemic phosphonates
DF Wiemer - Tetrahedron, 1997 - Elsevier
1 Introduction. Phosphonic acids and their phosphonate derivatives are common in the literature
of organic chemistry where they are employed in synthetic operations leading to carbon-…
of organic chemistry where they are employed in synthetic operations leading to carbon-…
An antifungal terpenoid defends a neotropical tree (Hymenaea) against attack by fungus-growing ants (Atta)
SP Hubbell, DF Wiemer, A Adejare - Oecologia, 1983 - Springer
Foragers of the leafcutting ant, Atta cephalotes L. (Formicidae, Attini) seldom or never attack
many of the plant species available to them in nature. In the semideciduous forests of …
many of the plant species available to them in nature. In the semideciduous forests of …
[HTML][HTML] Synthesis of a phosphoantigen prodrug that potently activates Vγ9Vδ2 T-lymphocytes
Phosphoantigen-sensitive Vγ9Vδ2 T cells are important responders to infections and
malignancy. However, the mechanisms by which phosphoantigens stimulate Vγ9Vδ2 T cells are …
malignancy. However, the mechanisms by which phosphoantigens stimulate Vγ9Vδ2 T cells are …
Hypericum in infection: Identification of anti-viral and anti-inflammatory constituents
…, ES Wurtele, JD Neighbors, DF Wiemer… - Pharmaceutical …, 2009 - Taylor & Francis
The Iowa Center for Research on Botanical Dietary Supplements seeks to optimize Echinacea,
Hypericum, and Prunella botanical supplements for human-health benefit, emphasizing …
Hypericum, and Prunella botanical supplements for human-health benefit, emphasizing …
Chemical leaf repellency to an attine ant: seasonal distribution among potential host plant species
The chemical repellency of leaves to the leaf—cutting, fungus—growing ant Atta cephalotes
was surveyed for 42 plant species randomly selected from the dry forest of Santa Rosa …
was surveyed for 42 plant species randomly selected from the dry forest of Santa Rosa …
Synthesis and biological activity of isoprenoid bisphosphonates
Bisphosphonates have been used in the clinic to treat osteoporosis and to reduce bone
resorption and the accompanying pathological bone fractures that attend a number of …
resorption and the accompanying pathological bone fractures that attend a number of …
Toxicity of terpenoid deterrents to the leafcutting antAtta cephalotes and its mutualistic fungus
Four natural products, of varying activity as deterrents of leafcutter attack, were tested for their
effects on ant survival and on the growth of the mutualistic attine fungus. The substances …
effects on ant survival and on the growth of the mutualistic attine fungus. The substances …
Phosphonate and bisphosphonate analogues of farnesyl pyrophosphate as potential inhibitors of farnesyl protein transferase
SA Holstein, DM Cermak, DF Wiemer, K Lewis… - Bioorganic & medicinal …, 1998 - Elsevier
Several phosphonate and bisphosphonate analogues of farnesyl pyrophosphate have been
prepared for an examination of their ability to inhibit farnesyl protein transferase (FPTase). A …
prepared for an examination of their ability to inhibit farnesyl protein transferase (FPTase). A …