User profiles for David H. Farb
 | David H Farb, Ph.D.Boston University School of Medicine Verified email at bu.edu Cited by 9195 |
[PDF][PDF] Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.
FS Wu, TT Gibbs, DH Farb - Molecular pharmacology, 1991 - researchgate.net
The N-methyl-D-aspartate(NMDA) receptor is believed to play a major role in learning and in
excitotoxic neuronal damage associated with stroke and epilepsy. Pregnenolone sulfate, a …
excitotoxic neuronal damage associated with stroke and epilepsy. Pregnenolone sulfate, a …
From ion currents to genomic analysis: Recent advances in GABAA receptor research
LE Rabow, SJ Russek, DH Farb - Synapse, 1995 - Wiley Online Library
The γ‐aminobutyric acid type A (GABA A ) receptor represents an elementary switching
mechanism integral to the functioning of the central nervous system and a locus for the action of …
mechanism integral to the functioning of the central nervous system and a locus for the action of …
[HTML][HTML] Sulfated and unsulfated steroids modulate γ-aminobutyric acidA receptor function through distinct sites
…, A Malayev, RH Purdy, TT Gibbs, DH Farb - Brain research, 1999 - Elsevier
Sulfated and unsulfated neurosteroids such as pregnenolone sulfate, dehydroepiandrosterone
sulfate (DHEAS), pregnanolone, and allopregnanolone, modulate ionotropic amino acid …
sulfate (DHEAS), pregnanolone, and allopregnanolone, modulate ionotropic amino acid …
17β-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors
CE Weaver Jr, M Park-Chung, TT Gibbs, DH Farb - Brain research, 1997 - Elsevier
Several lines of evidence suggest that 17β-estradiol (βE 2 ) has neuroprotective properties.
The risk and severity of dementia are decreased in women who have received estrogen …
The risk and severity of dementia are decreased in women who have received estrogen …
Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia
TL Yaksh, DH Farb, SE Leeman, TM Jessell - Science, 1979 - science.org
… Sandler, MB H. Youdim, E. Harrington, Nature (London) 230, 335 (1974); MB … H.-YT
Yang and NH Neff, J. Pharmacol. … The depletion of spinaiS-HT is associated with a reduction …
Yang and NH Neff, J. Pharmacol. … The depletion of spinaiS-HT is associated with a reduction …
Distinct Sites for Inverse Modulation ofN-Methyl-D-Aspartate Receptors by Sulfated Steroids
…, RH Purdy, AA Malayev, TT Gibbs, DH Farb - Molecular …, 1997 - ASPET
Steroid sulfation occurs in nervous tissue and endogenous sulfated steroids can act as positive
or negative modulators ofN-methyl-d-aspartate (NMDA) receptor function. In the current …
or negative modulators ofN-methyl-d-aspartate (NMDA) receptor function. In the current …
Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids
A Malayev, TT Gibbs, DH Farb - British journal of pharmacology, 2002 - Wiley Online Library
The neurosteroid pregnenolone sulphate (PS) potentiates N‐methyl‐D‐aspartate (NMDA)
receptor mediated responses in various neuronal preparations. The NR1 subunit can …
receptor mediated responses in various neuronal preparations. The NR1 subunit can …
[PDF][PDF] Inverse modulation of gamma-aminobutyric acid-and glycine-induced currents by progesterone.
FS Wu, TT Gibbs, DH Farb - Molecular pharmacology, 1990 - Citeseer
The ability of certain synthetic and endogenous steroids to modulate neuronal responses to
y-aminobutync acid (GABA) is well documented, but little is known of the effect of steroids on …
y-aminobutync acid (GABA) is well documented, but little is known of the effect of steroids on …
[PDF][PDF] 3 alpha-Hydroxy-5 beta-pregnan-20-one sulfate: a negative modulator of the NMDA-induced current in cultured neurons.
M Park-Chung, FS Wu, DH Farb - Molecular pharmacology, 1994 - Citeseer
We have shown previously that the neurosteroid pregnenolone sulfate acts as a positive
allostenc modulator at the N-methyl-D-aspartate(NMDA) receptor while inhibiting the kainate, …
allostenc modulator at the N-methyl-D-aspartate(NMDA) receptor while inhibiting the kainate, …
Geometry and charge determine pharmacological effects of steroids on N-methyl-D-aspartate receptor-induced Ca2+ accumulation and cell death
…, RH Purdy, KG Richards, TT Gibbs, DH Farb - … of Pharmacology and …, 2000 - ASPET
Modulation of N-methyl-d-aspartate (NMDA) receptor function by a series of sulfated steroids
and dicarboxylic acid ester analogs of pregnenolone sulfate and pregnanolone sulfate was …
and dicarboxylic acid ester analogs of pregnenolone sulfate and pregnanolone sulfate was …