The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …

Migraine is a disabling neurological disorder, diagnosis of which is based on clinical criteria.
A shortcoming of these criteria is that they do not fully capture the heterogeneity of migraine…

Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological functions.
Its two isoforms (α and β) are widely expressed throughout the body in sensory neurons …

The calcitonin/CGRP family of peptides includes calcitonin, α and β CGRP, amylin, adrenomedullin
(AM) and adrenomedullin 2/intermedin (AM2/IMD). Their receptors consist of one of …

Amylin is a pancreatic β-cell hormone that produces effects in several different organ
systems. Here, we review the literature in rodents and in humans on amylin research since its …

Our conceptual understanding of the molecular architecture of G-protein coupled receptors (GPCRs)
has transformed over the last decade. Once considered as largely independent …

Calcitonin (CT) receptors dimerize with receptor activity-modifying proteins (RAMPs) to create
high-affinity amylin (AMY) receptors, but there is no reliable means of pharmacologically …

Objective The trigeminovascular system plays a central role in migraine, a condition in need
of new treatments. The neuropeptide, calcitonin gene‐related peptide ( CGRP ), is proposed …

Calcitonin gene-related peptide (CGRP) plays a pivotal role in migraine, activating its
cognate receptor to initiate intracellular signalling. This atypical receptor comprises a distinct …

It is now recognized that G protein–coupled receptors (GPCRs), once considered largely
independent functional units, have a far more diverse molecular architecture. Receptor activity-…