Recent studies have shown that microRNA (miRNA) regulates gene expression by repressing
translation or directing sequence-specific degradation of complementary mRNA. Here, we …

Recent studies have shown that small noncoding RNAs, such as microRNAs and siRNAs,
regulate gene expression at multiple levels including chromatin architecture, transcription, …

Genistein (4′,5,7-trihydroxyisoflavone) is the most abundant isoflavone found in the soybean.
The effects of genistein on various cancer cell lines have been extensively studied but the …

MicroRNAs (miRNAs) are a class of small non-coding RNAs (ncRNAs) that regulate gene
expression by repressing translation or triggering the degradation of complementary mRNA …

Androgen receptor (AR) is a ligand-activated transcription factor belonging to the steroid
hormone receptor family and is very important for the development and progression of prostate …

Background Checkpoint inhibitors (CPIs) such as anti-PD (L)-1 and anti-CTLA-4 antibodies
have resulted in unprecedented rates of antitumor responses and extension of survival of …

We recently reported that synthetic dsRNAs targeting promoter regions can induce gene
expression in a phenomenon referred to as dsRNA-induced gene activation/RNA activation (…

The incidence and mortality of prostate cancer (PC) is approximately 2‐fold higher among
African‐Americans as compared to Caucasians and very low in Asian. We hypothesize that …

USP7 is a promising target for cancer therapy as its inhibition is expected to decrease function
of oncogenes, increase tumor suppressor function, and enhance immune function. Using …

β-Catenin and transcriptional factor TCF-4 (human T-cell factor-4) genes comprise the Wnt
signal. The Wnt signal pathway plays an important role in malignant transformation. We …